Sökning: "Aldol"

Visar resultat 16 - 20 av 30 avhandlingar innehållade ordet Aldol.

1. 16. Exploiting enzyme promiscuity for rational design

   Författare :Cecilia Branneby; Karl Hult; Alex Zaks; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Candida antarctica lipase B; alanine racemase; substrate specificity; reaction specificity; enzyme catalytic promiscuity; Biokemi; Biochemistry; Biokemi;

   Sammanfattning : Enzymes are today well recognized in various industrial applications, being an important component in detergents, and catalysts in the production of agrochemicals, foods, pharmaceuticals, and fine chemicals. Their large use is mainly due to their high selectivity and environmental advantage, compared to traditional catalysts. LÄS MER

3. 17. Aldolases for Enzymatic Carboligation : Directed Evolution and Enzyme Structure-Function Relationship Studies

   Författare :Huan Ma; Mikael Widersten; Wolf-Dieter Fessner; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; aldolase; 2-deoxyribose-5-phosphate aldolase; fructose-6-phosphate aldolase; directed evolution; enzyme dynamics; Biokemi; Biochemistry;

   Sammanfattning : The research summarized in this thesis focuses on directed evolution and enzyme mechanism studies of two aldolases: 2-deoxyribose-5-phosphate aldolase (DERA) and fructose-6-phosphate aldolase (FSA).Aldolases are nature’s own catalysts for one of the most fundamental reactions in organic chemistry: the formation of new carbon-carbon bonds. LÄS MER

4. 18. Rational redesign of Candida antarctica lipase B

   Författare :Anders Magnusson; Karl Hult; Bernhard Hauer; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Candida antarctica lipase B; rational redesign; secondary alcohols; substrate-assisted catalysis; S-selective; entropy; aldolase; stereospecificity pocket; oxyanion hole.; Biokemi; Biochemistry; Biokemi;

   Sammanfattning : This thesis describes the use of rational redesign to modify the properties of the enzyme Candida antarctica lipase B. Through carefully selected single-point mutations, we were able to introduce substrate-assisted catalysis and to alter the reaction specificity. LÄS MER

5. 19. Amino acid-catalyzed synthesis of amino acid derivatives : Application and semi-synthesis of Paclitaxel, Docetaxel and their derivatives

   Författare :Pawel Dziedzic; Armando Córdova; Stephen Hanessian; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Organocatlysis; amino acids; syntesis; Taxol and Taxotere derivatives; Chemistry; Kemi; organisk kemi; Organic Chemistry;

   Sammanfattning : This thesis deals with different applications of organocatalysis, where amino acid derivatives and small peptides are applied as catalysts. First, the development of environmentally friendly aldol reactions, carried out in aqueous media is illustrated. The corresponding β-hydroxy ketones are formed with ee´s up to 99%. LÄS MER

7. 20. Synthesis, characterization and applications of hierarchical porous inorganic materials: a multi-dimensional approach

   Författare :Junzhong Lin; Junliang Sun; Xinwen Guo; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Zeolites; Porous material; Hierarchical; Synthesis; Catalysis; MFI zeolite; MWW zeolite; ZSM-5; TS-1; Inorganic Chemistry; oorganisk kemi;

   Sammanfattning : Zeolites are a type of microporous crystalline materials that have been widely used in industrial applications including separation, adsorption, and catalysis. However, great limitations on diffusion through these materials can arise due to the small pores present in mircoporous frameworks, and this can impact catalytic reactions in particular. LÄS MER