Sökning: "enzyme dynamics"
Visar resultat 1 - 5 av 118 avhandlingar innehållade orden enzyme dynamics.
1. Optimizing Enzyme Immobilization in Mesoporous Silica - A Spectroscopic Study of the Dynamics and Spatial Distribution of the Confined Enzymes
Sammanfattning : Enzymes as biological catalysts are immobilized in porous materials to improve the enzyme activity and simplify their purification from the reaction media in biocatalytic applications. Mesoporous silica (MPS) particles are used as a promising support material for the immobilization of enzymes. LÄS MER
2. Transaminase Biocatalysis: Applications and Fundamental Studies
Sammanfattning : Biocatalysis is the branch of science at the intersection between chemistry and biology and specifcally dedicated to the application of natural evolvable catalysts, i.e. enzymes, in human-designed chemical processes. Among the array of promising biocatalysts, transaminases (EC 2. LÄS MER
3. On Catalytic Mechanisms for Rational Enzyme Design Strategies
Sammanfattning : Enzymes enable life by promoting chemical reactions that govern the metabolism of all living organisms. As green catalysts, they have been extensively used in industry. However, to reach their full potential, engineering is often required, which can benefit from a detailed understanding of the underlying reaction mechanism. LÄS MER
4. Molecular Simulation of Enzyme Catalysis and Inhibition
Sammanfattning : The reaction mechanisms for the hemoglobin degrading enzymes in the Plasmodium falciparum malaria parasite, plasmepsin II (Plm II) and histo-aspartic protease (HAP), have been analyzed by molecular simulations. The reaction free energy profiles, calculated by the empirical valence bond (EVB) method in combination with molecular dynamics (MD) and free energy perturbation (FEP) simulations are in good agreement with experimental data. LÄS MER
5. Dynamics of Enzyme Immobilization in Mesoporous Silica Particles
Sammanfattning : The focus of this thesis is placed on the dynamic behavior of proteins in confining environments which is studied as a scientific challenge for a deeper understanding of the immobilization mechanism and a better designing of enzyme immobilization in porous materials. Enzymes are immobilized in porous materials to improve the enzyme activity and simplify their purification from the product solution in biocatalytic applications. LÄS MER