Sökning: "Adipose Tissue metabolism"

Visar resultat 16 - 20 av 170 avhandlingar innehållade orden Adipose Tissue metabolism.

1. 16. The role of galectin-1 in type 2 diabetes. Clinical and experimental studies

   Författare :Emanuel Fryk; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; galectin-1; type 2 diabetes; human; adipose tissue; metabolism;

   Sammanfattning : Aim: The purpose of this thesis was to identify a new agent in the subcutaneous adipose tissue and assess its clinical potential in the context of type 2 diabetes. Study I: Through a combination of microdialysis and mass-spectrometry, we found increased galectin-1 levels in the subcutaneous adipose tissue in a small experimental study of 15 men with and without type 2 diabetes. LÄS MER

3. 17. Alterations in peripheral glucocorticoid metabolism : effects of weight changes

   Författare :Kotryna Simonyté; Cecilia Mattsson; Bo Angelin; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 11ß Hydroxysteroid dehydrogenase 1; obesity; glucocorticoids; cortisol; phosphoenolpyruvate carboxykinase; adipose tissue; liver; Endocrinology; Endokrinologi; medicin; Medicine;

   Sammanfattning : Background: An important role has been suggested for tissue-specific glucocorticoid metabolism in the development of obesity and its complications. 11ß hydroxysteroid dehydrogenase 1 (11ßHSD1) is an enzyme that catalyzes the interconversion of biologically inactive cortisone to active cortisol, thereby regulating its access to glucocorticoid receptors in target tissues. LÄS MER

4. 18. Foxf2 and Foxc2, two transcription factors that regulate adipocyte metabolism

   Författare :Rickard Westergren; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; forkhead genes; insulin signaling; glucose metabolism; adipose tissue; angiogenesis; Foxc2; Foxf2; Irs1; insulin resistance; Ang-2;

   Sammanfattning : Type 2 diabetes is the most common metabolic disorder today and has reached epidemic proportions in many countries. Diet-induced insulin resistance plays a central role in the development of type 2 diabetes. LÄS MER

5. 19. Mechanisms underlying metabolic alterations in Huntington's disease. Beyond the brain and back

   Författare :Elna Dickson; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Huntington s disease; huntingtin; metabolism; hypothalamus; adipose tissue;

   Sammanfattning : Huntington’s disease is caused by a mutation in the gene that codes for the protein huntingtin (HTT). A therapeutic strategy for Huntington’s disease is to lower the levels of huntingtin in the brain. However, multiple clinical trials have been stopped due to adverse effects. LÄS MER

7. 20. Myosin 1c taking adrenergic metabolism for a spin : More than a motor protein

   Författare :Alice Åslund; Tore Bengtsson; Michael Czech; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glucose uptake; Glucose transporter; Brown adipose tissue; White adipose tissue; Skeletal muscle; Myosin1c; Nuclear myosin I; Physiology; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : Metabolic diseases like type II diabetes (T2D) and obesity largely stems from an unbalanced energy homeostasis with the fails of the insulin pathway to the point in which the glucose homeostasis is severely disturbed leading to hyperglycemia. We have investigated if the β-adrenergic signaling pathways, in both brown adipose tissue (BAT) and skeletal muscle, could be used as a strategy to alleviate metabolic disease. LÄS MER