Sökning: "insulin signaling"

Visar resultat 1 - 5 av 239 avhandlingar innehållade orden insulin signaling.

  1. 1. Regulation of intracellular signaling events that modulate insulin action

    Författare :Silvia Gogg; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ; insulin; insulin resistance; EGF; Gab 1; insulin receptor substrate; PI3-kinase; Thiazolidinediones; PPARã; insulin signaling; glucose transport; adipose tissue; â-cell.;

    Sammanfattning : Insulin regulates several mechanisms of fundamental importance to the body involving glucose, fat andprotein metabolism. Insulin resistance in skeletal muscle, liver and adipose tissue promotes an increaseddemand for insulin secretion. LÄS MER

  2. 2. Fat cell insulin resistance : an experimental study focusing on molecular mechanisms in type 2 diabetes

    Författare :Frida Renström; Jan Eriksson; Anna Krook; Umeå universitet; []
    Nyckelord :AGRICULTURAL SCIENCES; LANTBRUKSVETENSKAPER; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; adipocyte; insulin signaling; insulin; glucose; IRS-1; glucose uptake; insulin resistance; typ 2 diabetes; serum; Medicine; Medicin;

    Sammanfattning : The aim of the present thesis was to further increase our understanding of mechanisms contributing to and maintaining cellular insulin resistance in type 2 diabetes (T2D). For this reason, the effects of high glucose and insulin levels on glucose transport capacity and insulin signaling, with emphasis on insulin receptor substrate 1 (IRS-1) were assessed in fat cells. LÄS MER

  3. 3. Adrenergic signaling in insulin-sensitive tissues

    Författare :Daniel L. Yamamoto; Tore Bengtsson; Barbara Cannon; Michael Cawthorne; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Metabolism; Adrenergic; Glucose; Signaling; Skeletal muscle; Animal physiology; Zoofysiologi; zoofysiologi; Zoological physiology;

    Sammanfattning : Glucose metabolism in insulin-sensitive tissues such as skeletal muscle and adipose tissue is tightly regulated by external stimuli. Metabolic changes in these tissues have direct effects on whole body metabolism. Such metabolic changes can be induced or influenced by adrenergic stimulation. LÄS MER

  4. 4. Morphological and functional effects of insulin signaling and the bHLH transcription factor Dimmed on different neuron types in Drosophila

    Författare :Yiting Liu; Dick R. Nässel; Irene Miguel-Aliaga; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; insulin signaling; Dimm; neuropeptide; insulin receptor; insulin-like peptide; drosophila; funktionell zoomorfologi; Functional Zoomorphology;

    Sammanfattning : In Drosophila, the insulin signaling pathway is at the interface between dietary conditions and control of growth and development, reproduction, stress responses and life span. Eight insulin like peptides (Dilp1-8), an insulin tyrosine kinase receptor (dInR) and its downstream components, as well as a relaxin-like receptor type (Lgr3) form the core of this signaling. LÄS MER

  5. 5. Insulin signaling dynamics in human adipocytes : Mathematical modeling reveals mechanisms of insulin resistance in type 2 diabetes

    Författare :Elin Nyman; Peter Strålfors; Gunnar Cedersund; Pierre De Meyts; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Type 2 diabetes is characterized by raised blood glucose levels caused by an insufficient insulin control of glucose homeostasis. This lack of control is expressed both through insufficient release of insulin by the pancreatic beta-cells, and through insulin resistance in the insulin-responding tissues. LÄS MER