Sökning: "Irs1"
Visar resultat 1 - 5 av 17 avhandlingar innehållade ordet Irs1.
1. Molecular Genetic Studies on Prostate and Penile Cancer
Sammanfattning : This thesis is comprised of two parts. In the first part we study the influence of four frequently disputed genes on the susceptibility for developing prostate cancer, and in the second part we attempt to establish a basic understanding of the molecular genetic events in penile cancer. LÄS MER
2. Foxf2 and Foxc2, two transcription factors that regulate adipocyte metabolism
Sammanfattning : Type 2 diabetes is the most common metabolic disorder today and has reached epidemic proportions in many countries. Diet-induced insulin resistance plays a central role in the development of type 2 diabetes. LÄS MER
3. Insulin signalling in human adipocytes : mechanisms of insulin resistance in type 2 diabetes
Sammanfattning : Prevalensen av fetma ökar drastiskt i stora delar av världen och utgör en stor riskfaktor för att utveckla insulinresistens och typ 2 diabetes. Fettväven kan bli mycket stor om för mycket energi tas upp av kroppen. LÄS MER
4. Caveolae structure and importance in insulin action
Sammanfattning : Type II diabetes is a disease characterized by chronic hyperglycaemia and abnormalities in lipid metabolism that affects approximately 5% of the population in the Western World. Caveolae are invaginations of the plasma membrane, described as 25-150 nm omega shaped structures, which are enriched in cholesterol, sphingolipids and the constituent protein caveolin. LÄS MER
5. A molecular approach to insulin signalling and caveolae in primary adipocytes
Sammanfattning : The prevalence of type II diabetes is increasing at an alarming rate due to the western world lifestyle. Type II diabetes is characterized by an insulin resistance distinguished by impaired glucose uptake in adipose and muscle tissues. LÄS MER