Sökning: "Abeta"

Visar resultat 11 - 15 av 42 avhandlingar innehållade ordet Abeta.

  1. 11. Interactive mechanism between beta-amyloid process, alfa7 nicotinic receptor, glial cell activation and oxidative stress in Alzheimer's disease

    Författare :Wen-Feng Yu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Abeta; Alzheimer s disease; astrocytes; brain development; nAChRs; neuritic plaques oxidative stress; transgenic mice; knockout mice;

    Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia with pathological features including the accumulation of neuritic plaques (NPs) and neurofibrillary tangles (NFTs). These degenerative processes are also accompanied by impaired cholinergic transmission, oxidative stress, activated glia and inflammation reaction. LÄS MER

  3. 12. Characterization of the Alzheimer's disease-associated clac protein

    Författare :Linda Söderberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer's disease (AD) is the most prevalent form of dementia in elderly people and is neuropathologically characterized by the presence of extracellular senile plaques (SPs) in the brain. SPs are mainly composed of the amyloid beta-peptide (Abeta), proteolytically derived from the amyloid beta-precursor protein by sequential cleavages performed by beta- and gammasecretase, to generate Abeta species of 40 and 42 amino acids, respectively. LÄS MER

  4. 13. Beta-amyloid processing and alpha7 neuronal nicotinic acetylcholine receptors in Alzheimer's disease-related mouse models : interactive mechanisms with focus on new drug targets

    Författare :Monika M Hedberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Accumulation of beta-amyloid (Abeta), neuronal loss and changes in neurotransmitter systems, in particular the cholinergic system, are consistent features of Alzheimer s disease (AD). Abeta is thought to play a critical role in the pathogenesis of AD and it has therefore become a target of interest as regards a therapeutic approach. LÄS MER

  5. 14. Statin treatment and beta-Amyloid Production in Patients with Alzheimer s Disease

    Författare :Kina Höglund; Göteborgs universitet; []
    Nyckelord :Alzheimer s disease; amyloid precursor protein; beta-amyloid; cholesterol; statins; CSF;

    Sammanfattning : Alzheimer s disease (AD) is a progressive neurodegenerative disorder pathologically characterized by neurofibrillary tangles and amyloid plaques. According to the amyloid cascade hypothesis, the increased production of beta-amyloid (Abeta), derived form the amyloid precursor protein (APP), and its aggregation into plaques are key pathological events, driving neurodegeneration in AD. LÄS MER

  7. 15. Affibody molecules for proteomic and therapeutic applications

    Författare :Caroline Grönwall; Stefan Ståhl; Lena Jendeberg; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody; protein engineering; phage display; amyloid beta peptide; transferrin; CD25; IL-2 receptor; proteomics; Bioengineering; Bioteknik;

    Sammanfattning : This thesis describes generation and characterization of Affibody molecules with future applications in proteomics research, protein structure determinations, therapeutic treatment of disease and medical imaging for in vivo diagnostics. Affibody molecules are engineered affinity proteins developed by combinatorial protein engineering from the 58-residue protein A-derived Z domain scaffold. LÄS MER