Sökning: "brain development"

Visar resultat 1 - 5 av 1082 avhandlingar innehållade orden brain development.

  1. 1. Regulation of site-selective A-to-I RNA editing : During mammalian brain development

    Författare :Helene Wahlstedt; Marie Öhman; Mary O'connell; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; RNA editering; ADAR; brain development; Molecular biology; Molekylärbiologi; Molecular Biology; molekylärbiologi;

    Sammanfattning : Adenosine (A) to inosine (I) RNA editing is a widespread post-transcriptional mechanism in mammals that contributes to increase the protein diversity. Adenosine deaminases that act on RNA (ADARs) are the enzymes catalyzing RNA editing. ADARs are particularly active within the brain where they act on transcripts involved in neurotransmission. LÄS MER

  3. 2. A-to-I RNA editing : Function and consequences during brain development

    Författare :Ylva Ekdahl; Marie Öhman; Kazuko Nishikura; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNA editing; miRNAs; Brain development; Molecular Biology; molekylärbiologi;

    Sammanfattning : The aim of my thesis has been to study how A-to-I RNA editing of miRNAs is regulated during brain development and the biological function of these editing events.Using high throughput RNA sequencing, we performed an unbiased search for edited, mature miRNAs in total mouse brain tissue from three developmental stages. LÄS MER

  4. 3. MRI Studies of the Fetal Brain and Cranium

    Författare :Nuno Canto Moreira; Johan Wikström; Raii Raininko; Daniela Prayer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fetal MRI; Brain; Cranium; Development; Normal; Ear; Lip; Palate; Biometry; Hippocampus; Measurements; Radiologi; Radiology;

    Sammanfattning : Ultrasound is the primary modality for fetal imaging, but Magnetic Resonance Imaging nowadays has a valuable complementary role as it often reveals findings that alter pregnancy management. Knowledge on some clinically relevant areas of the normal fetal development is still lacking, and this was the aim of this project. LÄS MER

  5. 4. Development of central catecholaminergic neuronal systems in the lizard Anolis sagrei

    Författare :Agneta Rehn; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; double labelling; immunohistochemistry; interplexiform cells; amacrine cells; catecholamines; development; retina; Reptiles; brain; Zoology; Zoologi;

    Sammanfattning : Catecholamines, comprising the neurotransmitters dopamine (DA), noradrenaline (NA) and adrenaline (A) are synthesized by specific enzymes (tyrosine hydroxylase (TH), dopamine ß-hydroxylase (DBH), phenylethanolamine-N-methyltransferase (PNMT)) in the central nervous system. The development and distribution of different catecholaminergic systems have been described in both the brain and retina of the lizard Anolis sagrei. LÄS MER

  7. 5. Development and Applications of in vitro Models to Study Human Brain Evolution and Disease

    Författare :Daniela Grassi; Molekylär neurogenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neural reprogramming; Neural differentiation; Brain development; Huntington s disease; Induced Neuron; Neural Progenitor Cell; Brain evolution;

    Sammanfattning : Neuroscience focusing on human development and disease has long been hampered due to ethical reasons, low tissue availability, and low translatability from animal models. To circumvent these obstacles, we have developed two methods for the investigation of human neural cells in culture. LÄS MER