Sökning: "AChE"

Visar resultat 1 - 5 av 29 avhandlingar innehållade ordet AChE.

  1. 1. Institutional Capacity for Territorial Cohesion

    Författare :Lisa van Well; Folke Snickars; Mats Johansson; Peter Ache; KTH; []

    Sammanfattning : Territorial cohesion has its legal basis in the Treaty of Lisbon and is one of the overarching goals in the 2007-2013 Cohesion Policy instruments. Still the definition of territorial cohesion can be characterized as a ‘moving target’ - each EU Member State and region conceptualizes the policy goal in as befits the specific regional challenges and opportunities of the territory. LÄS MER

  2. 2. Pesticide use in rice farming and its impacts on climbing perch (Anabas testudineus) in the Mekong Delta of Vietnam

    Författare :Thanh Tam Nguyen; Håkan Berg; Michael Tedengren; Cong Van Nguyen; Joachim Sturve; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Mekong Delta; Rice field; Climbing perch; Insecticide; Chlorpyrifos ethyl; Fenobucarb; Mixture; Sequential applications; AChE; naturgeografi; Physical Geography;

    Sammanfattning : The intensification of agricultural production in the Mekong Delta has faced serious challenges with respect to increased use of agrochemicals and especially pesticides. The indiscriminate use of pesticide could potentially impact on the long-term food production, environmental and human health in the delta. LÄS MER

  3. 3. Mammalian brain acetylcholinesterase : a study of its solubilization, purification, molecular state and interactions with cholinergic ligands including an endogenous modulator

    Författare :Bertil Niklasson; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Affinity chromatography; caudate nucleus; acetylcholinesterase; tetracaine; décaméthonium; d-tubocurarine; edrophonium; fluoride ion; hysteric properties; endogenous ligands to AChE;

    Sammanfattning : Membrane bound AChE from calf brain caudate nucleus was solubilized by use of ion-free media in presence of 10~ M EDTA and 10“5M tetracaine. The irreversible release of AChE was more effectively inhibited by divalent ions compared to monovalent ions added to the medium. LÄS MER

  4. 4. Selective inhibition of acetylcholinesterase 1 from disease-transmitting mosquitoes : design and development of new insecticides for vector control

    Författare :Cecilia Engdahl; Anna Linusson; Fredrik Ekström; Zoran Radić; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; acetylcholinesterase; non-covalent inhibitor; vector control; insecticide; mosquito; vector-borne disease; high throughput screening; rational design; biokemi; Biochemistry; datorlingvistik; computational linguistics;

    Sammanfattning : Acetylcholinesterase (AChE) is an essential enzyme with an evolutionary conserved function: to terminate nerve signaling by rapid hydrolysis of the neurotransmitter acetylcholine. AChE is an important target for insecticides. LÄS MER

  5. 5. Exploring non-covalent interactions between drug-like molecules and the protein acetylcholinesterase

    Författare :Lotta Berg; Anna Linusson; Fredrik Ekström; Joel L. Sussman; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; acetylcholinesterase; drug discovery; density functional theory; hydrogen bond; nerve-agent antidote; non-covalent interaction; protein-ligand complex; structure-based design; thermodynamics; X-ray crystallography; datorlingvistik; computational linguistics;

    Sammanfattning : The majority of drugs are small organic molecules, so-called ligands, that influence biochemical processes by interacting with proteins. The understanding of how and why they interact and form complexes is therefore a key component for elucidating the mechanism of action of drugs. LÄS MER