Sökning: "ABD"

Visar resultat 16 - 20 av 40 avhandlingar innehållade ordet ABD.

1. 16. Tumor targeted delivery of cytotoxic payloads using affibody molecules and ABD-derived affinity proteins

   Författare :Hao Liu; Torbjörn Gräslund; Stefan Ståhl; Nick Devoogdt; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Targeted tumor therapy; immunotoxins; ADCs; affibody molecule; ADAPT; pseudomonas exotoxin A; maytansinoid; Bioteknologi; Biotechnology;

   Sammanfattning : Cancer treatment cost billions of dollars every year, but the mortality rate is still high. An ideal treatment is the so-called “magic bullets” that recognize and kill tumor cells while leaving normal cells untouched. LÄS MER

3. 17. Hydrogen diffusion and ion implantation in silicon carbide

   Författare :Martin Janson; KTH; []
   Nyckelord :heat abd tgernidtbanucs; electronics and electrical; materials science;

   Sammanfattning : Secondary ion mass spectrometry (SIMS) has been employed tostudy the spatial distributions resulting from mass transportby diffusion and ion implantation in single crystal siliconcarbide (SiC). By a systematic analysis of this data,fundamental processes that govern these phenomena have beenderived. LÄS MER

4. 18. Exploitation of interactions with the neonatal Fc receptor to manipulate biological half-lives for therapeutic applications

   Författare :Shengze Yu; Torbjörn Gräslund; Mats Ohlin; KTH; []
   Nyckelord :Glioblastoma Multiforme GBM ; Prolacin Prl ; Prolacin receptor PrlR ; Prolactin antagonist PrlRA ; Albumin binding domain ABD ; serum albumin SA ; half-life extension; FcRn; Affibody; human growth hormone hGH ; immunoglobulin G IgG ; blocking; autoimmune disease; Bioteknologi; Biotechnology;

   Sammanfattning : Protein engineering provides powerful tools to create useful proteins with desired properties. In this thesis, rational design principles have been used for development of fusion proteins that can interact with the neonatal Fc receptor (FcRn) for potential medical applications. FcRn is widely expressed in the human body. LÄS MER

5. 19. Development of ADAPT-based tracers for radionuclide molecular imaging of cancer

   Författare :Javad Garousi; Vladimir Tolmachev; Tony Lahoutte; Uppsala universitet; []
   Nyckelord :ADAPT; scaffold protein; albumin-binding domain ABD ; Affinity protein; HER2; radionuclide molecular imaging;

   Sammanfattning : ABD-Derived Affinity Proteins (ADAPTs) is a novel class of small engineered scaffold proteins based on albumin-binding domain (ABD) of streptococcal protein G. High affinity ADAPT  binders against various therapeutic targets can be selected. LÄS MER

7. 20. Protein engineering to explore and improve affinity ligands

   Författare :Martin Linhult; KTH; []
   Nyckelord :binding; affinity; human serum albumin HSA ; albumin-binding domain ABD ; affinity chromatography; deamidation; protein A; stabilization; Z-domain; capacity; protein G; cleaning-in-place CIP ; protein engineering; C2 receptor;

   Sammanfattning : In order to produce predictable and robust systems forprotein purification and detection, well characterized, small,folded domains descending from bacterial receptors have beenused. These bacterial receptors, staphylococcal protein A (SPA)and streptococcal protein G (SPG), possess high affinity to IgGand / or HSA. LÄS MER