Sökning: "immunotoxins"

Hittade 3 avhandlingar innehållade ordet immunotoxins.

1. 1. Tumor targeted delivery of cytotoxic payloads using affibody molecules and ABD-derived affinity proteins

   Författare :Hao Liu; Torbjörn Gräslund; Stefan Ståhl; Nick Devoogdt; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Targeted tumor therapy; immunotoxins; ADCs; affibody molecule; ADAPT; pseudomonas exotoxin A; maytansinoid; Bioteknologi; Biotechnology;

   Sammanfattning : Cancer treatment cost billions of dollars every year, but the mortality rate is still high. An ideal treatment is the so-called “magic bullets” that recognize and kill tumor cells while leaving normal cells untouched. LÄS MER

3. 2. Targeting HER2-expressing tumors with potent drug conjugates and fusion toxins based on scaffold proteins

   Författare :Haozhong Ding; Torbjörn Gräslund; Stefan Ståhl; Harald Kolmar; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Targeted therapy; affibody molecules; ADAPT molecules; AffiDC; fusion toxins; HER2; Biotechnology; Bioteknologi;

   Sammanfattning : Targeted therapy is an emerging treatment for a variety of cancers. Small- sized scaffold proteins are an alternative to conventional antibody-based targeting molecules. LÄS MER

4. 3. The role of the mitochondrion in organotin-induced T-cell apoptosis

   Författare :Hélène Stridh; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Apoptosis plays a central role in the development and the function of the immune system. The cell death program can, however, be inappropriately activated or suppressed under pathological conditions. Several toxins have been shown to interfere with intra-thymic processes, thereby contributing to autoimmune disorders. LÄS MER