Sökning: "C2 receptor"

Visar resultat 1 - 5 av 17 avhandlingar innehållade orden C2 receptor.

  1. 1. Protein engineering to explore and improve affinity ligands

    Författare :Martin Linhult; KTH; []
    Nyckelord :binding; affinity; human serum albumin HSA ; albumin-binding domain ABD ; affinity chromatography; deamidation; protein A; stabilization; Z-domain; capacity; protein G; cleaning-in-place CIP ; protein engineering; C2 receptor;

    Sammanfattning : In order to produce predictable and robust systems forprotein purification and detection, well characterized, small,folded domains descending from bacterial receptors have beenused. These bacterial receptors, staphylococcal protein A (SPA)and streptococcal protein G (SPG), possess high affinity to IgGand / or HSA. LÄS MER

  3. 2. Molecular factors influencing epithelial-mesenchymal transition in breast cancer

    Författare :Gisela M A Nilsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer; epithelial-mesenchymal transition; c-erbB2; E-cadherin; NFI-C2; FoxF1; LOX;

    Sammanfattning : Epithelial-mesenchymal transition (EMT) is a developmental process defined by loss of epithelial characteristics and acquisition of mesenchymal phenotype. EMT or similar processes are also implicated in carcinoma cell invasion and the progression of breast carcinoma to metastasis. LÄS MER

  4. 3. Gene expression in human adipose tissue. Studies of leptin and genes selected by expression profiling

    Författare :Britt Gabrielsson; Göteborgs universitet; []
    Nyckelord :obesity; subcutaneous; omental; DNA microarray; sulfonylurea receptor; fibroblast; growth factors; complement system; fibroblast;

    Sammanfattning : Obesity, and in particular the amount of visceral adipose tissue, is correlated to development of type 2diabetes and cardiovascular disease. The aim of this thesis was to study genes expressed in humanadipose tissue that could be involved in regional adipose tissue homeostasis and/or obesity-associateddisease. LÄS MER

  5. 4. Adenovirus-mediated CD40 Ligand Immunotherapy of Prostate and Bladder Cancer

    Författare :Helena Dzojic; Magnus Essand; Thomas H Tötterman; Aristides Eliopoulos; Uppsala universitet; []
    Nyckelord :Medicine; immunotherapy; gene therapy; prostate cancer; bladder cancer; adenoviral vector; CD40 ligand; promoter; PPT; TSTA; depsipeptide FK228; TRAMP-C2; Medicin;

    Sammanfattning : Cancer immunotherapy aims at reversing the immunosuppressive tumor environment and enhancing anti-tumor immunity. This thesis comprises studies on murine models for prostate (TRAMP-C2) and bladder (MB49) cancer with the aim to explore if the introduction of an adenoviral vector expressing CD40 ligand (AdCD40L) can induce anti-tumor immune responses. LÄS MER

  7. 5. Chiral Pyridine-Containing Ligands for Asymmetric Catalysis. Synthesis and Applications

    Författare :Fredrik Rahm; KTH; []
    Nyckelord :asymmetric catalysis; chiral ligand; chiral pool; oxazoline; crown ether; ditopic receptor; bipyridine; pyridyl alcohol; modular approach; P; N-ligand; diethylzinc; allylic alkylation;

    Sammanfattning : This thesis deals with the design and syntheses of chiral,enantiopure pyridinecontaining ligands and their applicationsin asymmetric catalyis.Chiral pyridyl pyrrolidine ligands and pyridyl oxazolineligands were synthesized and employed in thepalladium-catalysed allylic alkylation of 1,3-diphenyl-2-propenyl acetate with dimethyl malonate. LÄS MER