Sökning: "deamidation"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet deamidation.

  1. 1. Protein engineering to explore and improve affinity ligands

    Författare :Martin Linhult; KTH; []
    Nyckelord :binding; affinity; human serum albumin HSA ; albumin-binding domain ABD ; affinity chromatography; deamidation; protein A; stabilization; Z-domain; capacity; protein G; cleaning-in-place CIP ; protein engineering; C2 receptor;

    Sammanfattning : In order to produce predictable and robust systems forprotein purification and detection, well characterized, small,folded domains descending from bacterial receptors have beenused. These bacterial receptors, staphylococcal protein A (SPA)and streptococcal protein G (SPG), possess high affinity to IgGand / or HSA. LÄS MER

  3. 2. Engineering Proteinaceous Ligands for Improved Performance in Affinity Chromatography Applications

    Författare :Susanne Gülich; KTH; []
    Nyckelord :affinity chromatography; cleaning-in-place; deamidation; destabilization; linker engineering; protein engineering; stabilization; staphylococcal protein A; streptococcal protein G; turn loop engineering;

    Sammanfattning : .... LÄS MER

  4. 3. Fighting isoaspartate

    Författare :Jijing Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Isoaspartate (IsoAsp) is a damaging amino acid residue generated either from asparagine (Asn) deamidation or aspartate (Asp) isomerization. Both reactions are spontaneous in physiological conditions and require no enzymes. In isoAsp, a CH2 group is rearranged from the side chain and extends the polypeptide backbone. LÄS MER

  5. 4. Aging and heat-sealing properties of films based on wheat gluten

    Författare :Sung-Woo Cho; Mikael Hedenqvist; Minna Hakkarainen; Mikael Lindström; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; wheat gluten; aging; migration; opacity; heat sealability; shear strength; Polymer chemistry; Polymerkemi;

    Sammanfattning : Recently the research interest of the possibility of using wheat gluten (WG) as packaging material has greatly increased due to its combination of high gas barrier, attractive mechanical, film-forming and renewable properties. The source is also readily available and inexpensive on a worldwide basis. LÄS MER

  7. 5. Transport and metabolism of opioid tetrapeptide agonists with a focus on oral and respiratory delivery

    Författare :Eva Krondahl; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; opioid peptides; permeability; metabolism; oral delivery; pulmonary delivery; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

    Sammanfattning : The clinical development of peptide drugs for oral delivery has often been hindered because of poor transport across the intestinal membranes and degradation in the gastrointestinal tract and liver. Alternative delivery routes through more permeable membranes preferably with less pronounced proteolytic activity, such as the nasal and pulmonary routes, have therefore been considered. LÄS MER