Sökning: "5-HT receptors"

Visar resultat 16 - 20 av 61 avhandlingar innehållade orden 5-HT receptors.

  1. 16. Galanin : a modulator of serotonin neurotransmission : relevance for depression

    Författare :Haleh Razani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :galanin; 5-HT1A receptors; 5-HT; 8-OH-DPAT; fluoxetine; robalzotan; passive avoidance; microdialysis; mRNA; KD values; Bmax values; depression;

    Sammanfattning : Galanin is widely distributed throughout the central nervous system with multiple and diverse biological roles. In the rat, galanin-like immunoreactivity is expressed in a population of5-hydroxytryptamine (5-HT, serotonin) neurons in the dorsal raphe (DR) with extensive projections to the forebrain areas e.g., hippocampus. LÄS MER

  3. 17. Novel insights into the role of serotonin in control of β-cell fuction

    Författare :Hedvig Bennet; Celiaki och diabetes; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Inadequate insulin secretion is a central component in the development of Diabetes Mellitus, resulting from reduced pancreatic β-cell mass, as well as diminished β-cell function. Islet produced 5-hydroxy tryptamine (5-HT) is suggested to regulate insulin secretion and β-cell mass in rodents during pregnancy and in metabolically challenged states. LÄS MER

  4. 18. Experimental studies on the sources, pathways and targets for volume transmission in the rat brain

    Författare :Anders Jansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :volume transmission; extracellular space; monoamines; Dl D2 receptors; 5HT2A receptors; nitric oxide; interleukin-1ß; cholecystokinin; galanin;

    Sammanfattning : Volume transmission has been defined as the three-dimensional diffusion or convection of transmitters in the extracellular space (ECS) and cerebrospinal fluid (CSF) over a larger distance than the synaptic cleft. The regional localization of dopamine (DA) nerve terminals and dopamine Dl and D2 receptors in nucleus accumbens were studied in detail using double immuno-labelling. LÄS MER

  5. 19. Significance of serotonin for pain, allodynia, and hyperalgesia in the human masseter muscle

    Författare :Malin Ernberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Anxiety; Double-Blind Method; 5-Hydroxytryptamine; Fibromyalgia; Hyperalgesia; Masseter muscle; Microdialysis; Pain threshold; Visual Analogue Pain Scale;

    Sammanfattning : The main aim of this thesis was to investigate the hypothesis that serotonin (5-HT) is involved in the pathophysiology of human chronic muscle pain. The thesis comprises a clinical and a human experimental part. LÄS MER

  7. 20. Receptor-ligand interactions of the human 5-HT1B receptor : A site-directed mutagenesis study

    Författare :Charlotta Grånäs; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; 5-hydroxytryptamine; serotonin; 5-HT1B receptor; site-directed mutagenesis; signal transduction; sumatriptan; G protein; Neurovetenskap; Neurology; Neurologi; medicinsk farmakologi; Medical Pharmacology;

    Sammanfattning : The 5-hydroxytryptamine (5-HT, serotonin)1B receptor is one of thirteen G protein-coupled 5-HT receptors. 5-HT is known to influence temperature regulation, pain, cognition and sexual and feeding behaviours. LÄS MER