Sökning: "5HT2A receptors"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden 5HT2A receptors.

  1. 1. Serotonergic receptor subtypes in learning and memory : Focus on 5-HT1A, 5-HT1B and 5-HT2A receptors

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Neuroscience

    Författare :Maria Lüttgen; Karolinska Institutet.; Karolinska Institutet.; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Serotonin; 5-HT1A receptor; 5-HT1B receptor; 5-HT2A receptor; acetylcholine; NMDA receptor; water maze; passive avoidance; septum; hippocampus; teaming; memory; immunohistochemistry; mRNA;

    Sammanfattning : The aim of this thesis was to study how serotonin (5-HT) receptor subtypes can influence hippocampus/amygdala-dependent teaming and memory using the water maze (WM) and the passive avoidance (PA) tasks in rodents, and to provide a cellular correlate to the behavioral results using histochemical methods. Glutamatergic neurons in the trisynaptic circuit of the hippocampus are believed to be important for spatial teaming and memory as well as synaptic plasticity. LÄS MER

  2. 2. Experimental studies on the sources, pathways and targets for volume transmission in the rat brain

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Neuroscience

    Författare :Anders Jansson; Karolinska Institutet.; Karolinska Institutet.; [1999]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; volume transmission; extracellular space; monoamines; Dl D2 receptors; 5HT2A receptors; nitric oxide; interleukin-1ß; cholecystokinin; galanin;

    Sammanfattning : Volume transmission has been defined as the three dimensional diffusion or convection of transmitters in the extracellular space (ECS) and cerebrospinal fluid (CSF) over a larger distance than the synaptic cleft. The regional localization of dopamine (DA) nerve terminals and dopamine Dl and D2 receptors in nucleus accumbens were studied in detail using double immuno-labelling. LÄS MER

  3. 3. Clinical molecular imaging of schizophrenia

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Clinical Neuroscience

    Författare :Mirjam Talvik; Karolinska Institutet.; Karolinska Institutet.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PET; D2 D3 receptors; 5HT2A receptors; antipsychotic drugs; schizophrenia; age effects; raclopride; FLB 457; M100907; clozapine; haloperidol; perphenazine; thalamus; cortex; striatum; PANSS;

    Sammanfattning : The aim of this thesis was to examine pathophysiology and antipsychotic treatment of schizophrenia by using positron emission tomography (PET). The high affinity radioligand [11C]FLB 457 was used for determination of dopamine D2 receptor binding in the thalamus and the cortex of nine drug-naïve patients with schizophrenia and eight control subjects. LÄS MER

  4. 4. PET studies of the serotonin transporter in the human brain

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Clinical Neuroscience

    Författare :Johan Lundberg; Karolinska Institutet.; Karolinska Institutet.; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; positron emission tomography; MADAM; WAY 100635; 5-HTT; 5-HT1A receptors; receptor occupancy; major depressive disorder; citalopram; escitalopram;

    Sammanfattning : The serotonin (5-HT) system attracts considerable attention in research on the pathophysiology and drug treatment of neuropsychiatric disorders. The brain imaging technique Positron Emission Tomography (PET) allows for examination of neurotransmission systems in the human brain in vivo. LÄS MER

  5. 5. Cytokine induced airway hyperreactivity characterized in an in-vitro model of asthma

    Detta är en avhandling från Laboratory of Clinical and Experimental Allergy Research, Department of Otorhinolaryngology, Institute of Clinical Science, Malmö University Hospital, Lund University, Sweden

    Författare :Yaping Zhang; Lunds universitet.; Lund University.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; toxicology; Farmakologi; farmakognosi; MAPK; TNF-alpha; 5-HT; Respiratory system; Andningsorganen; Pharmacological sciences; pharmacognosy; pharmacy; interleukin-1beta; hyperresponsiveness; endothelin-1; airway; bradykinin; toxikologi; farmaci;

    Sammanfattning : Popular Abstract in Swedish Astma är en sjukdom som karakteriseras av upprepade anfall av andningssvårigheter, orsakade av kramp, slemhinnesvullnad och segt sekret i luftvägarna. Den finns beskriven i texter redan från det antika Grekland och rapporteras idag vara en sjukdom med utbredning över hela vårt klot. LÄS MER