Sökning: "5 P2"

Visar resultat 21 - 25 av 53 avhandlingar innehållade orden 5 P2.

  1. 21. Studies on the activation of cytosolic phospholipase A2 and 15-lipoxygenase-1

    Författare :Erik Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Arachidonic acid is a polyunsaturated fatty acid, which has four double bonds and belongs to the omega-6 family of fatty acids. Even if it can be formed in humans from one essential fatty acid, the linoleic acid, most of the arachidonic acid in the body comes with the intake of food. LÄS MER

  3. 22. Design and Synthesis of Acyclic and Macrocyclic Peptidomimetics as Inhibitors of the Hepatitis C Virus NS3 Protease

    Författare :Anna Lampa; Anja Sandström; Youla Tsantrizos; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; hepatitis C virus; HCV; NS3 protease inhibitor; structure-activity relationship; phenylglycine; ring-closing metathesis; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : Hepatitis C is a blood-borne disease affecting 130-170 million people worldwide. The causative agent, hepatitis C virus (HCV), infects the liver and is the major reason for chronic liver disease worldwide. The HCV NS3 protease, a key enzyme in the virus replication cycle, has been confirmed to be an important target for drug development. LÄS MER

  4. 23. Experimental and Clinical Studies on Platelet Receptors in Cardiovascular Disease

    Författare :Oscar Braun; Kardiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; inflammation; athersosclerosis; platelets; thrombosis; Cardiovascular system; Kardiovaskulära systemet;

    Sammanfattning : The crucial role of platelets in maintaining primary hemostais has been evident for a long time and there is now also mounting evidence for their involvement in inflammation. In combination with aspirin, inhibition of the platelet P2Y12 ADP receptor with clopidogrel has become a cornerstone in the antiplatelet in acute coronary syndromes. LÄS MER

  5. 24. P-type ATPases studied by electron microscopy and two-dimensional crystallization

    Författare :Kenneth Yijing Xian; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :electron microscopy; ion transport; membrane protein; P-type ATPase; two-dimensional crystallization;

    Sammanfattning : Electron microscopy and two-dimensional crystallography have been used to study the molecular structures of the porcine renal Na+,K+-ATPase and the porcine gastric H+,K+-ATPase. In addition, morphological changes have been observed with electron cryomicroscopy from tubulovesicles in porcine gastric mucosae. LÄS MER

  7. 25. Influence of MHC class I peptide interaction on antigen presentation in normal and malignant cells

    Författare :Qian-Jin Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cytotoxic T lymphocytes; Natural Killer cells; Epstein-Barr virus; MHC class I; class I binding motifs; T cell receptor; antigen presentation; immunodominance;

    Sammanfattning : The presentation of MHC class I peptide complexes in normal and malignant cells was studied. An HLA A11 binding motif was defined by comparing synthetic peptide analogues of a known cytotoxic T Iymphocyte (CTL) target epitope for induction of surface A11 expression and triggering of cytotoxic activity. LÄS MER