Sökning: "5 P2"

Visar resultat 6 - 10 av 53 avhandlingar innehållade orden 5 P2.

  1. 6. Phosphoinositides control insulin secretion through multiple routes

    Författare :Phuoc My Nguyen; Christina Bark; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Phosphoinositides; PI 4 P; PI 4; 5 P2; Ca2 ; optogenetics; VDCC; Sac2; OSBP; OSW-1; cholesterol; membrane contact sites;

    Sammanfattning : Glucose-stimulated insulin secretion from pancreatic beta cells is the sequence of events that starts with glucose uptake and ends with the fusion of insulin granules with the plasma membrane through Ca2+-triggered exocytosis. Phosphoinositides are minor components of all cellular membranes, yet play fundamental roles as regulators of many cellular processes. LÄS MER

  3. 7. Membrane lipids and their transfer proteins in β-cells

    Författare :Beichen Xie; Olof Idevall-Hagren; Anders Tengholm; Jen Liou; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ca2 ; PKC; E-Syt1; TMEM24; ER-PM contact; PI 4; 5 P2; phosphoinositides; β-cell; insulin; optogenetics; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Sammanfattning : Insulin secretion from β-cells is essential for glucose homeostasis and is often dysregulated in diabetes. Intracellular Ca2+ and membrane lipids cooperate to control insulin secretion with high spatial and temporal precision. LÄS MER

  4. 8. Lipid Signalling Dynamics in Insulin-secreting β-cells

    Författare :Anne Wuttke; Anders Tengholm; Erik Gylfe; Louis Philipson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ATP; β-cell; diacylglycerol; insulin secretion; oscillations; PtdIns 4 P; PtdIns 4; 5 P2; protein kinase C; P2Y receptor; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Certain membrane lipids are involved in intracellular signalling processes, among them phosphoinositides and diacylglycerol (DAG). They mediate a variety of functions, including the effects of nutrients and neurohormonal stimuli on insulin secretion from pancreatic β-cells. LÄS MER

  5. 9. Lysogenic or lytic cycle of bacteriophage P2 : a transcriptional switch

    Författare :Shamol Saha; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP;

    Sammanfattning : .... LÄS MER

  7. 10. Site-Specific Recombination : Integrases, Accessory Factors and DNA Targets of P2-like Coliphages

    Författare :Lina Sylwan; Elisabeth Haggård-Ljungquist; Margaret C. M. Smith; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Genetics; Genetik; molekylärgenetik; Molecular Genetics;

    Sammanfattning : The temperate coliphage P2 and its family members integrate their genomes into the host Escherichia coli chromosome by a site-specific recombination mechanism to form lysogeny. Integration takes place between the complex phage attP site and the simple bacterial attB site and is catalyzed by the phage encoded integrase (Int). LÄS MER