Sökning: "MHC class I"

Visar resultat 1 - 5 av 197 avhandlingar innehållade orden MHC class I.

  1. 1. The quality control of MHC class I antigen presentation

    Författare :Kajsa M Paulsson; Antigen presentation; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chaperone; assembly; COPI; antigenic peptide; TAP; MHC; tapasin; Immunology; serology; transplantation; Immunologi; serologi;

    Sammanfattning : Major histocompatibility complex (MHC) class I molecules present antigenic peptides to CD8+ T cells. The peptides are generated by proteasomes in the cytosol, then translocated across the membrane of the endoplasmic reticulum (ER) by the transporter associated with antigen processing (TAP). LÄS MER

  3. 2. Avian MHC: variation and selection in the wild

    Författare :Helena Westerdahl; MEMEG; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; polymorphism; balancing selection; cDNA; avian malaria; great reed warbler; Djurekologi; bird; Animal ecology; immune defence; MHC class II; Major Histocompatibility Complex; MHC class I;

    Sammanfattning : In vertebrates the Major Histocompatibility Complex (MHC) plays a central role in the specific immune defence against various pathogens. Compared with other coding genes the MHC genes exhibit an extremely high level of polymorphism that is maintained by balancing selection. LÄS MER

  4. 3. MHC class I - Peptide binding and complex stability

    Författare :Elna Follin; Antigen presentation; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The major histocompatibility class I (MHC-I) genes are highly polymorphic and the proteins that they encode play a crucial role in both the innate and the adaptive immune response. A MHC-I molecule consists of three parts, one polymorphic heavy chain, one invariant light chain, β2-microglobulin and a peptide of usually between 8-11 amino acids in length. LÄS MER

  5. 4. NK cell inhibitory receptor interactions with MHC class I molecules

    Författare :Jonas Sundbäck; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NK cells; MHC class I molecules; inhibitory receptors;

    Sammanfattning : Natural killer (NK) cells represent the third population of lymphocytes in size after B- and T-cells. NK mediated killing of target cells is strongly influenced by MHC class I molecules expressed on target cells. In contrast to T-cells, NK cells can be inhibited by MHC class I molecules through the action of specific inhibitory NK cell receptors. LÄS MER

  7. 5. Lymphoid development and function in MHC class I deficient mice

    Författare :Sofia Freland; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MHC class I; T cell selection; cytotoxic T lymphocyte; antigen presentation; MHC class I deficient mice; NK cell; tumor growth;

    Sammanfattning : MHC class I molecules present short peptide fragments, derived from proteins synthesized in the cytosol, to specific CTL. The MHC class I molecule is a heterotrimer encompassed of a polymorphic transmembrane glycoprotein (heavy chain), ß2-microglobulin (ß2m), and a peptide. LÄS MER