Sökning: "5 P2"

Visar resultat 26 - 30 av 53 avhandlingar innehållade orden 5 P2.

  1. 26. Immunoregulation and immunotherapy in experimental autoimmune neuritis

    Författare :Li-Ping Zou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Experimental autoimmune neuritis (EAN) is a CD4+ T cell mediated autoimmune disease of the peripheral nervous system (PNS). EAN represents an animal model for studying the immunopathogenesis and immunotherapy of Guillain-Barré syndrome (GBS). LÄS MER

  3. 27. Synthesis of β-turn and pyridine based peptidomimetics

    Författare :David Blomberg; Jan Kihlberg; Kay Brickmann; Torbjörn Frejd; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Peptidomimetics; beta-turn; beta-strand; pyridine scaffold; Grignard exchange reaction; SNAr reaction; thrombin inhibitor; Leu-enkephalin.; Organic synthesis; Organisk syntes;

    Sammanfattning : Despite the unfavorable pharmacokinetic properties associated with peptides, they are still of great interest in drug development due to a multitude of interesting biological functions. The development of peptidomimetics strives to maintain or improve the biological activity of a peptide concurrently with removing the unwanted properties. LÄS MER

  4. 28. Development and application of new methods for anticancer drug discovery and early evaluation

    Författare :Sumeer Dhar; Uppsala universitet; []
    Nyckelord :Medical sciences; Drug development; tumor cell lines; cytotoxic drugs; neural network; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Sammanfattning : A non-clonogenic assay using the redox dye Alamar Blue and primary human tumor cells (PHTC) from patients and human tumor cell lines (HTCL) was established for rapid screening and evaluation of anticancer drugs. PHTC cultures from chronic lymphocytic leukemia (CLL) and ovarian carcinoma (Ovca) were compared with renal carcinoma (ACHN) and lymphocytic (CCRF-CEM) HTLCs in response to 63 toxic or non-toxic compounds. LÄS MER

  5. 29. Immunoregulation of experimental autoimmune neurirtis focuses on cell immunity

    Författare :Yu Zhu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Experimental autoimmune neuritis (EAN) is a CD4+ T cell mediated autoimmune disease of peripheral nervous system (PNS). EAN can be induced in susceptible animal strains by active immunization with peripheral nerve tissue, the purified peripheral nerve myelin components P2 and PO, or synthetic P2 and PO peptides. LÄS MER

  7. 30. Studies on T cells and cytokines in Guillain-Barré syndrome and experimental allergic neuritis

    Författare :Charlotte Rüdhmer-Dahle; Jan Ernerudh; Jan Hillert; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Guillain-Barrésyndrome (GBS) is an inflammatory disease of peripheral nerves, characterised by muscle weakness. The nerves are attacked and destroyed by the immune system. The symptoms usually progress over a few weeks and many patients become severely disabled. LÄS MER