Sökning: "11q."

Visar resultat 21 - 25 av 26 avhandlingar innehållade ordet 11q..

  1. 21. Telomere length as prognostic parameter in chronic lymphocytic leukemia

    Författare :Pawel Grabowski; Göran Roos; Ylva Paulsson Karlsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; telomere length; chronic lymphocytic leukemia; prognosis; longitudinal sampling; genomic aberrations; IGHV; CD38; ZAP70; prognostic factors; Pathology; Patologi; patologi; Pathology;

    Sammanfattning : B-cell chronic lymphocytic leukemia (B-CLL) is the most common leukemia among the adult population in western countries and accounts for 30-40% of all leukemias. With survival time ranging from months to decades, the clinical course of individual CLL patients is highly variable. LÄS MER

  3. 22. Molecular studies of acute myeloid leukemia and the telomerase reverse transcriptase gene

    Författare :Charlotta Lindvall; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Aacute myeloid leukaemia; telomerase hTERT; cancer cytogenetics; spectral karyotyping; gene expression profiling;

    Sammanfattning : Multiple chromosome rearrangements (MCRs) are detected in approximately 10% of patients with acute myeloid leukemia (AML), and are associated with an adverse prognosis. Comprehensive analysis of the chromosome rearrangements in these complex karyotypes has previously been hampered by the limitations of conventional cytogenetic techniques such as G-banding. LÄS MER

  4. 23. Molecular studies in breast cancer susceptibility genes

    Författare :Jindong Chen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :familial breast cancer; breast cancer susceptibility gene; BRCA1; BRCA2; ATM; TP53; PTEN MMAC1; STK11 LKB1; gene mutation; mutation screening; LOH;

    Sammanfattning : Breast cancer is the most common malignancy among women, with a cumulative risk of approximately 12% by the age of 85. Of the breast cancer cases, 5-10% are hereditary. LÄS MER

  5. 24. Studies of gene fusions and copy number alterations in salivary and adnexal neoplasms

    Författare :Marta Persson; Göteborgs universitet; []
    Nyckelord :cancer genetics; fusion oncogenes; chromosome translocation; MYB; NFIB; CRTC1; MAML2; salivary gland; breast; adenoid cystic carcinoma; mucoepidermoid carcinoma; hidradenoma;

    Sammanfattning : Cancer is a genetic disease caused by the accumulation of genetic changes such as mutations and chromosomal rearrangements. An increasing number of genetic studies of both hematological and solid neoplasms have shown that recurrent chromosome translocations often result in fusion oncogenes. LÄS MER

  7. 25. Genomic instability and tumor progression : a cytochemical, molecular biological and cytogenetic study of human tissue from uterine cervix, colon, breast and ovary

    Författare :Harald Blegen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cervical; colorectal; breast; ovarian neoplasia; proliferation; DNA ploidy; cyclins; P53; CGH;

    Sammanfattning : Disruption of cell cycle checkpoint control is believed to be common in human carcinomas. To elucidate how cell cycle defects and genomic instability cooperate we investigated the pathogenesis of carcinomas by using four different models of tumor progression in human tissue samples i.e. from the uterine cervix, colon, breast and ovary. LÄS MER