Sökning: "telomere length"

Visar resultat 1 - 5 av 46 avhandlingar innehållade orden telomere length.

  1. 1. Telomere length : dynamics and role as a biological marker in malignancy

    Författare :Ulrika Svenson; Göran Roos; Uwe Martens; Umeå universitet; []
    Nyckelord :Telomere length; peripheral blood; immune cells; breast cancer; renal cell carcinoma; biological marker; patologi; Pathology;

    Sammanfattning : Telomeres are protective structures at the end of our chromosomes, composed of multiple repeats of the DNA sequence TTAGGG. They are essential for maintaining chromosomal stability by preventing damage and degradation of the chromosome ends. LÄS MER

  2. 2. What modulates telomere dynamics? : Inheritance, developmental effects, and physiological challenges

    Författare :Ye Xiong; MEMEG; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Telomere; Telomere dynamics; Telomere length; telomere inheritance; Zebra finch; Immune challenge; Heritability; Taenopygia guttata; Physiological parameter;

    Sammanfattning : Telomeres are the conservative sequence repeats located at the end of linear chromosomes that have been the focus of intensive research across many disciplines over the last four decades. They function as a cap to protect the chromosome ends from fusion to other chromosomes and to prevent chromosome degradation. LÄS MER

  3. 3. Exposure, telomere length, and cancer risk

    Författare :Huiqi Li; Avdelningen för arbets- och miljömedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; exposure; telomere; methylation; chromosomal aberration; cancer risk; rubber fumes; arsenic; welding fumes; diesel exhaust; particulate matter;

    Sammanfattning : Telomeres are tandem repeats of TTAGGG at the end of eukaryotic chromosomes. Telomeres play a key role in chromosome stability and regulation of the cellular lifespan. Telomeres are shortened during cell division, and probably, by not yet well characterised factors in the environment. LÄS MER


    Författare :Asghar Muhammad; MEMEG; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Avian malaria; Plasmodium; qPCR; parasitemia; life history; reproduction; survival; feather growth; MHC; telomere length; heritability; telomere loss; fitness; wild population; Acrocephalus arundinaceus; Delichon urbica;

    Sammanfattning : Haemosporidia is a well-studied group of parasites, which infect mammals, reptiles and birds and use blood sucking vectors for their transmission. By conducting natural population studies and experimental infections, We have been able to detect and quantify Haemosporidia from avian blood to investigate how these pathogens affect their avian hosts. LÄS MER

  5. 5. Telomere length - inheritance pattern and role as a biomarker

    Författare :Katarina Nordfjäll; Göran Roos; Thomas von Zglinicki; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; telomere length; peripheral blood; inheritance; breast cancer; survival; polymorphism; Medical cell biology; Medicinsk cellbiologi;

    Sammanfattning : Telomeres are repetitive TTAGGG structures ending each chromosome and thereby protecting its integrity. Due to the end-replication problem, telomeres shorten with each cell division. When reaching a critical telomere length (TL), the cells stop dividing and enter replicative senescence. LÄS MER