Sökning: "LOH"

Visar resultat 1 - 5 av 54 avhandlingar innehållade ordet LOH.

  1. 1. RNA-mediated virulence gene regulation in the human pathogen Listeria monocytogenes

    Detta är en avhandling från Umeå, Sweden : Print & Media

    Författare :Edmund Loh; Umeå universitet.; Umeå universitet.; [2010]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Listeria monocytogenes; virulence; ncRNAs; PrfA; 5´-UTRs; NATURAL SCIENCES Biology Cell and molecular biology Molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : The Gram-positive human pathogen Listeria monocytogenes uses a wide range of virulence factors for its pathogenesis. The majority of its virulence genes are encoded on a 9-kb pathogenicity island and are controlled by the transcriptional activator PrfA. LÄS MER

  2. 2. Genetic studies of endocrine abdominal tumors

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Ola Hessman; Uppsala universitet.; [2001]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; MEN1; LOH; pancreatic endocrine tumors; midgut carcinoid; Smad4 DPC4; Kirurgi; MEDICINE Surgery; MEDICIN Kirurgi; Surgery; kirurgi;

    Sammanfattning : Pancreatic endocrine tumors (PETs) occur sporadically or in the familial multiple endocrine neoplasia type 1 (MEN1) syndrome, whereas midgut carcinoids are nonfamilial, malignant endocrine tumors of the intestine. For these tumor entities morphological criteria are of limited use for prognostic prediction and selection of treatment. LÄS MER

  3. 3. Molecular Pathogenesis of Cervical Carcinoma Analysis of Clonality, HPV16 Sequence Variations and Loss of Heterozygosity

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Xinrong Hu; Uppsala universitet.; [2001]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; cervical carcinoma; CIN; HPV; LOH; X-chromosome inactivation; clonality; molecular pathogenesis; Genetik; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik; Pathology; patologi;

    Sammanfattning : A previous model of morphological pathogenesis assumed that cervical carcinoma is of monoclonal origin and progresses through multiple steps from normal epithelium via CINS into invasive carcinomas. The aim of this study was to investigate the molecular mechanism of pathogenesis of cervical neoplasia. LÄS MER

  4. 4. Hereditary Breast Cancer in South Sweden. Early findings from studies on the role of BRCA1

    Detta är en avhandling från Department of Oncology, Clinical Sciences, Lund University

    Författare :Oskar Thor Johannsson; Lunds universitet.; Lund University.; [1997]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; survival analysis; CGH; mRNA in situ hybridization; germline mutations; LOH; Breast neoplasm; BRCA1; Cytology; oncology; cancerology; Cytologi; onkologi; cancer;

    Sammanfattning : The thesis presents the results from investigations into the role of BRCA1 in hereditary cancer in South Sweden. Loss of heterozygosity (LOH) studies found loss of the wildtype allele of BRCA1 to be common in BRCA1 associated breast cancer, but due to the high degree of LOH on chr. LÄS MER

  5. 5. Molecular mechanisms in cervical carcinogenesis : Studies of clonality, somatic genetic alterations and human papillomavirus variants in cervical pre-invasive and invasive cancer

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Zhongmin Guo; Uppsala universitet.; [2000]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; cervical cancer; CIN; clonality; X-chromosome inactivation; LOH; HPV; chromosome 3p; chromosome 6; Genetik; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik; Pathology; patologi;

    Sammanfattning : Cervical cancer derives from a series of pre-invasive cervical neoplastic lesions termed CIN I-III (Cervical Intraepithelial Neoplasia) via typical multiple-step processes. In contrast to premalignant disorders in other organs, different degrees of CIN possess a distinct biological behaviour where a proportion spontaneously regress or persist, whereas some progress to invasive cancer. LÄS MER