Sökning: "visceral adipose tissue"

Visar resultat 21 - 25 av 69 avhandlingar innehållade orden visceral adipose tissue.

  1. 21. Semi-mechanistic models of glucose homeostasis and disease progression in type 2 diabetes

    Författare :Steve Choy; Maria Kjellsson; Mats Karlsson; Willem de Winter; Andrea Mari; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; pharmacodynamics; pharmacometrics; glucose homeostasis; insulin; type 2 diabetes; obesity; weight; visceral adipose tissue; HbA1c; non-linear mixed effects; modelling; disease progression; ZDSD rats; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by consistently high blood glucose, resulting from a combination of insulin resistance and reduced capacity of β-cells to secret insulin. While the exact causes of T2DM is yet unknown, obesity is known to be a major risk factor as well as co-morbidity for T2DM. LÄS MER

  3. 22. Role of inflammatory and mitochondria genes in adipose tissue and obesity

    Författare :Maria Kaaman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Obesity is rapidly increasing in prevalence around the world together with its complications such as dyslipidemia, cardiovascular disease (CVD) and insulin resistance, which eventually may lead to type 2 diabetes (T2DM). The excess of adipose tissue, the hallmark of obesity, led us to study the adipose tissue as a contributor to obesity and insulin resistance. LÄS MER

  4. 23. Metabolic and endocrine function of human adipose tissue with focus on regional differences

    Författare :Vanessa van Harmelen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :acylation stimulating protein; adipocytes; adipose tissue heterogeneity; adrenoceptors; insulin; leptin; lipogenesis; lipolysis; noradrenaline; plasminogen activator inhibitor-1; preadipocytes; tumour necrosis factor-cc;

    Sammanfattning : The major function of human adipose tissue is to store excess ingested energy and to release free fatty acids after hydrolysis of triglycerides (lipolysis), to meet the energy demands of other organs. Adipose tissue also has a secretory function. LÄS MER

  5. 24. Significance of adipose tissue characteristics for development of metabolic complications in obesity

    Författare :Daniel P Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Obesity is closely related to development of insulin resistance and dyslipidemia. Intrinsic properties of adipose tissue are also of great importance for obesity related comorbidity. LÄS MER

  7. 25. Studies on the links between white adipose tissue phenotype and the circulatory system

    Författare :Jesper Bäckdahl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Obesity is a strong risk factor for cardiovascular disease. It is defined by an unhealthy excess of white adipose tissue (WAT). Adipose derived weight gains and losses are linked to changes in two other independent cardiovascular risk factors: hypertension, and arterial stiffness. LÄS MER