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Visar resultat 6 - 10 av 131 avhandlingar som matchar ovanstående sökkriterier.

1. 6. Protein tyrosine kinases in insulin producing cells : Expression and putative importance for beta-cell function

   Författare :Charlotte Öberg-Welsh; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Protein tyrosine kinase; insulin producing cells; fetal development; VEGF; Src-family; Bsk; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

   Sammanfattning : Protein tyrosine kinases are of importance for cell replication and differentiation in manysystems. The mechanisms controlling the replication and differentiation of insulin producingcells are unknown. LÄS MER

3. 7. FLT3 and KIT in acute myeloid leukemia. Translational studies on oncogenic signaling from receptor tyrosine kinases. : Translational studies on oncogenic signaling from receptor tyrosine kinases

   Författare :OSCAR LINDBLAD; Avdelningen för translationell cancerforskning; []
   Nyckelord :Acute myeloid leukemia; FLT3-ITD; KIT; tyrosine kinase receptors;

   Sammanfattning : .... LÄS MER

4. 8. Roles of hematopoietin and cytokine tyrosine kinase receptors in early lymphopoiesis

   Författare :Christina Jensen; Stamcellscentrum (SCC); []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IL -7; FLT3 Ligand; cytokines; lymphopoiesis; hematopoiesis; TSLP; apoptosis;

   Sammanfattning : Cytokines have been shown to have important roles in lymphopoiesis. However, many questions remain unresolved. Among other, while the action of interleukin (IL)-7 in alpha beta T cell development in mouse seems to be largely mediated through permissive survival signaling, the possible permissive role of IL-7 in early B cell development is disputed. LÄS MER

5. 9. Modulation of PDGF receptors function by posttranslational modifications

   Författare :Kehuan Wang; Carl-Henrik Heldin; Johan Lennartsson; Natalia Papadopoulos; Jean-Baptiste Demoulin; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF signaling; receptor tyrosine kinase; ubiquitination; DUB; STAT3; SUMO; SUMOylation; cleavage; autophagy; SQSTM1 p62; LC3; GABARAP; bafilomycin A1; Medicinsk biokemi; Medical Biochemistry; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : The platelet-derived growth factor receptors (PDGFRs) play important roles in multiple cellular processes including cell survival, cell growth and cell migration. Dysregulation of PDGFRs causes aberrant PDGF signaling, which leads to various diseases. LÄS MER

7. 10. Protein Tyrosine Phosphatases as Regulators of Receptor Ryrosine Kinases

   Författare :Camilla Persson; Arne Östman; Niels Peter Moller; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; protein tyrosine phosphatase; tyrosine kinase; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : Tyrosine phosphorylation is a crucial mechanism in cellular signaling and regulates proliferation, differentiation, migration and adhesion. The phosphorylation reaction is reversible and is governed by two families of enzymes: protein tyrosine kinases and protein tyrosine phosphatases (PTPs). LÄS MER