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Visar resultat 21 - 25 av 131 avhandlingar som matchar ovanstående sökkriterier.

  1. 21. Intratumoral Predictive Markers in Metastatic Renal Cancer Patients

    Författare :Marjut Niinivirta; Gustav Ullenhag; Gunilla Enblad; Sten Nilsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Renal cell cancer; predictive marker; tyrosine kinase inhibitor; tissue microarray; cubilin; annexin A1; PKLR; ELTD1; Oncology; Onkologi;

    Sammanfattning : There is no established predictive marker for the treatment of metastatic renal cell cancer (mRCC) patients. With a predictive marker, patients unlikely to respond could be selected upfront and offered other therapy options. Thereby, unnecessary toxicity could be avoided and costs would be reduced. LÄS MER

  3. 22. The role of Shb in ES cell differentiation, angiogenesis and tumor growth

    Författare :Nina Funa; Michael Welsh; Leif Jansson; Lars Holmgren; Uppsala universitet; []
    Nyckelord :Cell biology; Shb; tyrosine kinase signaling; ES; endoderm; mesoderm; apoptosis; microvasculature; tumor growth; Cellbiologi;

    Sammanfattning : Shb is a ubiquitously expressed adaptor protein with the ability to bind several tyrosine kinase receptors and intracellular signaling proteins. Previous studies have implied a wide spectrum of Shb-mediated cellular responses, which motivated me to further investigate the role of Shb in differentiation and angiogenesis. LÄS MER

  4. 23. Neurotrophic factors and their receptors structure-function relationships and signalling mechanisms

    Författare :Mikael Ryden; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :neurotrophins; nerve growth factor; brain-derived neurotrophic factor; neurotrophin-3; neurotrophin-4; p75 neurotrophin receptor; neuroblastoma; serinethreonine kinase receptors;

    Sammanfattning : Background: The development, survival and maintenance of the vertebrate nervous system requires the continuous supply of a set of polypeptides termed neurotrophic factors. Among these, the neurotrophins (NTs) and members of the transforming growth factor-B (TGF-B) superfamily have raised substantial hopes for future clinical applications. LÄS MER

  5. 24. Messenger molecules and receptors in the human trigeminovascular system

    Författare :Mingyan Hou; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsykologi; Neurologi; neurofysiologi; Neurology; neuropsychology; neurophysiology;

    Sammanfattning : The initiation of a migraine attack involves a primary central nervous system dysfunction with subsequent activation of the trigeminovascular system. In trigeminal ganglia, the expression of calcitonin gene-related peptide (CGRP), substance P (SP) and nitric oxide synthase (NOS) have been demonstrated by immunocytochemistry. LÄS MER

  7. 25. Regulation of neurotrophins and their receptors : molecular aspects and functional implications

    Författare :Tuija Salin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :neurotrophin; nerve growth factor; brain-derived neurotrophic factor; neurotrophin-3; neurotrophin-4; glia; gliosis; neuron; tyrosine kinase receptor; transgenic; null mutation; gene; exon; intron; mRNA;

    Sammanfattning : The aim of this work was to study the regulation of neurotrophins and their receptors in a functional aspect. The studies included analysis of neuronal and glial neurotrophin gene expression, that was investigated by using molecular biological techniques. LÄS MER