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Visar resultat 1 - 5 av 37 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Matrix metalloproteinases in natural killer cells. Expression of MMPs, IL-2 activation and killer cell interactions with Matrigel® and model tumours

    Författare :Per Albertsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Protease; matrix metalloproteinase; killer cell; IL-2; Matrigel; B16 melanoma; tumour infiltration; invasion assay; zymography; Western blot; RT-PCR; light microscopy; fluorescence; electron microscopy;

    Sammanfattning : Introduction: IL-2 activated natural killer (A-NK) cells can recognize malignant cells and exert tumouricidal activities by multiple mechanisms that require close contact with the target cells. Upon adoptive transfer, some A-NK cells accumulate in tumours by migrating from the vascular bed to a position inside the malignant tissue, forming close contacts with target cells. LÄS MER

  3. 2. Immune cell infiltration and prognosis in colorectal cancer

    Författare :Agnes Ling; Richard Palmqvist; Sofia Edin; Xingru Li; Ola Winqvist; Umeå universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Colorectal cancer; molecular subgroups; immune cell infiltration; immune escape; prognosis;

    Sammanfattning : Background: Colorectal cancer (CRC) is globally the second most common form of cancer among women, and third in men. It is also one of the most common causes of cancer-related death in high-income countries. Surgical resection is the basis for curative therapy but still almost half of the patients die from metastatic disease. LÄS MER

  4. 3. Tumour microenvironment in serous ovarian cancer

    Författare :Sara Corvigno; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Ovarian cancer is the seventh most common malignancy in women worldwide and the most lethal gynaecological malignancy in developed countries. The epithelial subtype is divided in five main histologic groups, of which the high-grade serous is the most common subtype. LÄS MER

  5. 4. Macrophage antigen expression in breast and colorectal cancers : A consequence of macrophage - tumour cell fusion?

    Författare :Ivan Shabo; Joar Svanvik; Bengt Gustavsson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Carcinogenesis is a sophisticated biological process consisting of a series of progressive changes in somatic cells from premalignant to malignant phenotype. Despite the vast information available about cancer cells, the origin of cancer and cause of metastasis still remain enigmatic. LÄS MER

  7. 5. Hodgkin Lymphoma – an Interplay Between Tumour Cell and Microenvironment

    Författare :Ingrid Glimelius; Gunilla Enblad; Daniel Molin; Rose-Marie Amini; Marie Fischer; Volker Diehl; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN; Oncology; onkologi;

    Sammanfattning : Hodgkin lymphoma (HL) is a malignant disorder characterised by few tumour cells surrounded by a massive infiltrate of inflammatory cells, fibrosis, and microvessels. Therefore, it is a good model in which to study the interplay between tumour cells and the microenvironment. LÄS MER