Sökning: "trkB"

Visar resultat 6 - 10 av 30 avhandlingar innehållade ordet trkB.

  1. 6. Neurotrophic factors in peripheral nervous system development : function and specificity

    Författare :Anna Stenqvist Castelo-Branco; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neurotrophic factors control a range of activities in developing neurons, including survival, proliferation, migration and neuronal differentiation. Two classes of neurotrophic factors that are strongly linked to neuronal development of the peripheral nervous system are the neurotrophins and GDNF family ligands. LÄS MER

  3. 7. Brain-derived neurotrophic factor and endocannabinoid functions in gabaergic interneuron development

    Författare :Paul Berghuis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Formation of the cerebral cortex is controlled by tightly regulated processes: the proliferation and survival decisions of neural progenitors, radial and tangential migration of neuronal precursors, axon guidance and dendritic growth underpinning the formation of synapses. Patterning of the neocortex has been extensively studied and significant progress has been made in understanding the principles of cortical neuronal circuit formation. LÄS MER

  4. 8. The role of glucocorticoid receptors and mitogen-regulated protein kinases in the cochlea

    Författare :Inna Meltser; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hearing loss induced by acoustic trauma is a common handicap for the human population. Acoustic trauma triggers a cascade of changes in the cochlea such as a direct mechanical damage of sensory hair cells, biochemical disturbances including reactive oxygen and nitrogen species generation, release of pro-inflammatory cytokines and exitotoxicity. LÄS MER

  5. 9. Survival and differentiation of central noradrenergic neurons

    Författare :Pontus Holm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : About half of all central noradrenergic (NA) neurons reside in the locus coeruleus (LC). Projections from the LC reach target regions throughout the entire brain and regulate a variety of functions, such as mood, vigilance, arousal, sleep, attention and memory acquisition. LÄS MER

  7. 10. Role of the brain derived neurotrophic factor and inflammatory mediators in colon cancer

    Författare :Syrina Mehrabi; Malmö Cellpatologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colon Cancer; Neutrophils; Inflammation; CysLT1R; BDNF; Tumor microenvironment; Prognostic; Predictive; Diagnostic; Gene signature; Biomarkers;

    Sammanfattning : CRC is one of the most common causes of cancer death in the world. If CRC is diagnosed in the early stages, the patient's chance of survival is estimated at about 90%, with a very low probability of recurrence. The five-year DFS for CRC patients in stage III and IV drops to 63.3% and 18. LÄS MER