Sökning: "Peptide self-assembly"

Visar resultat 1 - 5 av 18 avhandlingar innehållade orden Peptide self-assembly.

  1. 1. On the colloidal and molecular aspects of peptide self-assembly

    Författare :Axel Rüter; Fysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Peptide self-assembly; Aggregation kinetics; Peptide hydrogel; Small angle scattering; Rheology;

    Sammanfattning : Peptide self-assembly is a spontaneous process, ubiquitous in nature for the creation of highly ordered and complex biological structures, making it a sought after technique in the development of novel biocompatible materials. The process is also strongly associated with various neurodegenerative diseases in the formation of amyloid plaques in diseases such as Alzheimer’s and Parkinson’s, where fully functioning proteins aggregate are reassembled into nonfunctional fibrillar aggregates that eventually lead to cell death. LÄS MER

  2. 2. Modulation of Alzheimer's amyloid β peptide self-assembly : Insights into molecular mechanisms of peptide aggregation associated with Alzheimer's disease

    Författare :Axel Abelein; Astrid Gräslund; Adriaan Bax; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Biophysics; biofysik;

    Sammanfattning : Misfolding of proteins and peptides is closely linked to several neurodegenerative disorders, among them Alzheimer's disease (AD), the most prominent example of brain diseases. The self-assembly of the amyloid β peptide (Aβ) into amyloid fibrils is one histologic hallmark of AD. LÄS MER

  3. 3. Modulation of amyloid β peptide self-assembly : Aggregation mechanisms associated with Alzheimer's disease

    Författare :Axel Abelein; Astrid Gräslund; Magnus Wolf-Watz; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Biophysics; biofysik;

    Sammanfattning : .... LÄS MER

  4. 4. Biomimetic Formation of Calcium Phosphate Based Nanomaterials

    Författare :Wenxiao He; Chalmers University of Technology; []
    Nyckelord :NATURVETENSKAP; TEKNIK OCH TEKNOLOGIER; NATURAL SCIENCES; ENGINEERING AND TECHNOLOGY; superstructure; lyotropic liquid crystal; self-assembly; Calcium phosphate; bone-like apatite; amphiphilic peptide; nanocomposite; biomimetic mineralization;

    Sammanfattning : The intercellular material in bone is a nanocomposite of aligned “hard” inorganics—calcium phosphate (CaP) platelets embedded in the long-range ordered “soft” organic collagen matrix. This elaborate structural arrangement redeems the weaknesses of the individual components (being soft protein or brittle mineral) and gives bone its excellent mechanical properties for the protection and support of our bodies. LÄS MER

  5. 5. Alkylglycoside Surfactants - Self-Assembly, Solid-State Properties and Interactions with Hydrophobic Molecules

    Författare :Caroline Ericsson; Fysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Fysikalisk kemi; Physical chemistry; peptide stabilisation; solubilisation; micelle morphology; solid-state behaviour; alkylglycosides; nonionic surfactants;

    Sammanfattning : A thorough physical-chemical characterisation of alkylglycosides has been performed. The effects of temperature, salt, concentration and deuterium exchange on the self-aggregation of n-nonyl-b-D-glucoside (b-C9G1) and n-tetradecyl-b-D-maltoside (b-C14G2) have been studied in dilute solutions by static and dynamic light scattering, neutron scattering, rheology, capillary viscometry and tensiometry. LÄS MER