Sökning: "trkB"

Visar resultat 11 - 15 av 30 avhandlingar innehållade ordet trkB.

  1. 11. On the role of parvalbumin interneurons in neuronal network activity in the prefrontal cortex

    Författare :Nicolas Gustavo Guyon; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The prefrontal cortex (PFC) is an area important for executive functions, the initiation and temporal organization of goal-directed behavior, as well as social behaviors. Inhibitory interneurons expressing parvalbumin (PV) have a vital role in modulating PFC circuit plasticity and output, as inhibition by PV interneurons on excitatory pyramidal neurons regulates the excitability of the network. LÄS MER

  3. 12. Heavy metal neurotoxicity : on trimethyltin-, methylmercury- and cadmium-induced disturbances of neurotransmitter systems and neurotrophins

    Författare :Helena Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :neurotoxicity; trimethyltin; methylmercury; cadmium; development; GFAP; GABA; noradrenalin; BDNF; c-fos; hsp70; glial glutamate transporter;

    Sammanfattning : Organic and inorganic metal compounds produced by human activities often reach the environment where they are associated with a plethora of potential health hazards. Of particular concern is the risk for CNS disturbances during development or in the adult. LÄS MER

  4. 13. Antidepressive and antipsychotic treatments : effects on nerve growth factor and brain-derived neurotrophic factor in rat brain

    Författare :Francesco Angelucci; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Recently it has been reported that depression and schizophrenia, the two major psychiatric disorders, are characterized by loss of neurons in specific brain regions. Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are proteins involved in neuronal survival and plasticity of dopaminergic, cholinergic and serotonergic neurons in the central nervous system (CNS). LÄS MER

  5. 14. Neurotrophic factors and their receptors structure-function relationships and signalling mechanisms

    Författare :Mikael Ryden; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :neurotrophins; nerve growth factor; brain-derived neurotrophic factor; neurotrophin-3; neurotrophin-4; p75 neurotrophin receptor; neuroblastoma; serinethreonine kinase receptors;

    Sammanfattning : Background: The development, survival and maintenance of the vertebrate nervous system requires the continuous supply of a set of polypeptides termed neurotrophic factors. Among these, the neurotrophins (NTs) and members of the transforming growth factor-B (TGF-B) superfamily have raised substantial hopes for future clinical applications. LÄS MER

  7. 15. Changes in human uterine innervation in term pregnancy and labor occurence and roles of neurotrophins and TRPV1

    Författare :Berith Karlsson Tingåker; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Uterus; corpus uteri; cervix uteri; pregnancy; labor pain; neurotrophins; NGF; TRPV1; sensory corpuscles; human.;

    Sammanfattning : Objective: Cervical ripening, is a prerequisite for successful labor, which is often very painful and involves an inflammatory reaction. However, little is presently known con-cerning nerve-related changes in the human uterus during labor and the fundamental hy-pothesis tested here was that labor pain emanates primarily from the cervix uteri. LÄS MER