Sökning: "transgenic"

Visar resultat 21 - 25 av 551 avhandlingar innehållade ordet transgenic.

  1. 21. Functional Studies on the PDGFR α gene promoter and effects of autocrine PDGF-A stimulation in vivo

    Författare :Xiao-Qun Zhang; Hubert Schorle; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Autorcrine PDGF; promoter; PDGFRA; transgenic mice; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Platelet-derived growth factor receptor α (PDGFRα) plays an important role during embryogenesis. After implantation, the patterns of expression of Pdgfrα and its ligand Pdgf-A undergo an "autocrine-paracrine transition", in that Pdgf-A becomes expressed in the ectoderm and epithelia, while Pdgfrα is expressed in the adjacent mesenchymal tissue. LÄS MER

  3. 22. Targeting Early Stages of Alzheimer’s Disease in a Transgenic Model

    Författare :Anna Lord; Lars Nilsson; Lars Lannfelt; Frida Ekholm Pettersson; Thomas Bayer; Uppsala universitet; []
    Nyckelord :Geriatrics; geriatrik;

    Sammanfattning : The Arctic mutation causes early-onset Alzheimer’s disease (AD), and makes amyloid-β (Aβ) peptides more prone to form Aβ protofibrils. The aims of this thesis were to investigate the mechanisms of the Arctic mutation in vivo, and to use transgenic models to determine the role of early intermediates of Aβ aggregation, like protofibrils, in the pathogenesis. LÄS MER

  4. 23. Metabolic engineering of starch synthesis in barley

    Författare :Staffan Ahlandsberg; Sadequr Rahman; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; hordeum vulgare; plant breeding; starch; genetic engineering; transgenic plants; biokemi; Biochemistry;

    Sammanfattning : Starch is an important industrial raw material both for food and non-food purposes. In plants, starch is deposited in the leaf and in the storage tissues such as seed endosperm, roots or tubers. LÄS MER

  5. 24. Mutant superoxide dismutase-1-caused pathogenesis in amyotrophic lateral sclerosis

    Författare :Daniel Bergemalm; Stefan Marklund; Thomas Brännström; Peter Andersen; Caterina Bendotti; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; SOD1; mitochondria; proteome; transgenic mice; inclusion; Clinical chemistry; Klinisk kemi; biokemi; Biochemistry; neurologi; Neurology; Clinical Chemistry; klinisk kemi; patologi; Pathology;

    Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a devastating disease that affects people in their late mid-life, with fatal outcome usually within a few years. The progressive degeneration of neurons responsible for muscle movement (motor neurons) throughout the central nervous system (CNS) leads to muscle wasting and paralysis, and eventually affects respiratory function. LÄS MER

  7. 25. Metal Affinity Peptides in Biotechnological Applications As tools in protein purification, protein stabilisation, metal quantification and metal tolerance of bacteria and plants

    Författare :Malin Mejàre; Tillämpad biokemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cadmium; metal quantification; fusion tag; metal affinity tag; phage display; peptide library; metal tolerance; metal resistance; metal accumulation; bioremediation; transgenic plant; tobacco; potato; protein purification; immobilised metal affinity chromatography; metal affinity precipitation; metal detection; protein stabilisation; Bioteknik; Biotechnology; Biokemi; Metabolism; Biochemistry; metal ion;

    Sammanfattning : Metal affinity tags have been fused to proteins and demonstrated to function as tools in protein purification, protein stabilisation, quantitative metal analysis and metal tolerance of bacteria and plants. In biotechnological applications proteins frequently have to function in nonnatural environments with harsh conditions which impose requirements for high stability on the proteins. LÄS MER