Sökning: "PGC-1α"

Visar resultat 1 - 5 av 14 avhandlingar innehållade ordet PGC-1α.

  1. 1. Effects of PGC1a-induced exercise adaptations in muscle on plasticity and recovery mechanisms in the CNS

    Författare :Lars O Karlsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; muscle; brain; exercise; transgenic; PGC-1α; FNDC5; irisin;

    Sammanfattning : In this thesis, we sought to determine if muscle-derived exercise-induced signaling via PGC-1α muscle activation influences neuroplasticity under physiological or pathophysiological conditions. For this purpose, transgenic mice with muscle-specific overexpression of PGC-1α that display an endurance exercise muscle phenotype were evaluated in models of cranial irradiation and photothrombotic stroke, as well as in aging and in a voluntary running paradigm. LÄS MER

  3. 2. Exercise and regulation of metabolic function in human skeletal muscle : with special reference to PGC-1α and the mitochondria

    Författare :Eva-karin Gidlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Regular physical activity is highly associated with many health benefits and regular exercise training is used in the prevention and treatment of a large number of disease conditions, including type 2 diabetes, cardiovascular disease and cancer. One of the key adaptations to regular exercise training is mitochondrial biogenesis and improved oxidative capacity, particularly in skeletal muscle tissue. LÄS MER

  4. 3. Structure and function relationships in the PGC-1 family of transcriptional coactivators

    Författare :Manizheh Izadi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : PGC-1 coactivators are central regulators of several cellular processes, most notably the coupling between energy demands and supply. PGCs activate distinct biological processes in a tissue-specific manner. LÄS MER

  5. 4. The effect of different exercise regimens on mitochondrial biogenesis and performance

    Författare :Niklas Psilander; Kent Sahlin; Jostein Hallén; Gymnastik- och idrottshögskolan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin Teknik; Medicine Technology;

    Sammanfattning : Endurance training is a powerful tool to improve both health and performance. Physical activity is now recognized as an effective treatment and prevention therapy for a wide range of diseases. One of the most profound adaptations to endurance training is increased mitochondrial function and content within the exercising muscles. LÄS MER

  7. 5. Functional genomics approaches to dissect causal DNA variations in obesity and type 2 diabetes

    Författare :Mi Huang; Genetisk och molekylär epidemiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GWAS; Obesity; Type 2 diabetes; CRISPR Cas9; precision medicine; adipocytes; functional genomics;

    Sammanfattning : GWAS studies have identified hundreds of loci that associate with obesity and type 2 diabetes. However, the functional relevance of the genetic variants, and their impact on disease or traits, is largely unknown. LÄS MER