Sökning: "transgenic"

Visar resultat 11 - 15 av 551 avhandlingar innehållade ordet transgenic.

  1. 11. The role of GH in the regulation of energy homeostasis, lipid metabolism and cardiovascular function in transgenic mice

    Författare :Bob Olsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; growth hormone; cardiovascular disease; energy homeostasis; lipid metabolism; transgenic mice;

    Sammanfattning : The aim of this thesis was, using two transgenic models, to investigate some metabolic diseases associated with acromegaly e.g. hypertension and alterations in lipid and lipoprotein metabolism. LÄS MER

  3. 12. Function of contractile and cytoskeletal proteins in smooth muscle: Effects of hypertrophy and age and desmin removal in a transgenic animal

    Författare :Rolf Sjuve; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transgenic mouse; desmin; embryonic myosin; isoforms; myosin heavy chain; age; smooth muscle; hypertrophy; Physiology; Fysiologi;

    Sammanfattning : In man, the urinary bladder responds to an urinary outflow obstruction with a pronounced dilatation and growth of the bladder wall. This clinical situation can be mimicked in rat by creation of a partial urinary outflow obstruction and the papers included in the present thesis use this animal model to address questions regarding the adaptive changes in the smooth muscle of the growing bladder. LÄS MER

  4. 13. Expression and function of ribozymes in transgenic mice

    Författare :Michael Andäng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :hammerhead ribozyme; hairpin ribozyme; transgenic mice; HIV-1; pseudotype virus; cleavage products; cis-cleavage;

    Sammanfattning : Hammerhead and hairpin ribozymes are short RNAs that act as sequence-specific endoribonucleases by cleaving a target RNA after hybridization to complementary sequences. By changing the specific target hybridization sequence of the ribozyme, virtually any RNA can be targeted, making ribozymes a versatile tool for gene down-regulation (knockdown). LÄS MER

  5. 14. Characterization of Centrally Expressed Solute Carriers : Histological and Functional Studies with Transgenic Mice

    Författare :Sahar Roshanbin; Robert Fredriksson; David Engblom; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SLC; Solute carriers; Amino acid transporter; PAT; B0AT2; mTORC1; Medical Science; Medicinsk vetenskap;

    Sammanfattning : The Solute Carrier (SLC) superfamily is the largest group of membrane-bound transporters, currently with 456 transporters in 52 families. Much remains unknown about the tissue distribution and function of many of these transporters. LÄS MER

  7. 15. Life without mitochondrial DNA : studies of transgenic mice

    Författare :Jianming Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :mitochondrial disease; mitochondrial DNA mtDNA ; mitochondrial transcripton factor A Tfam ; cre-loxP; conditional knockout; transgenic; mitochondrial cardiomyopathy; apoptosis;

    Sammanfattning : Mitochondrial DNA (mtDNA) is a closed circular DNA genome that resides in the mitochondrial network. Mutations of mtDNA cause spontaneous and hereditary disorders known as mitochondrial diseases. Mitochondrial transcription factor A (Tfam) is a key factor for transcription of mtDNA in vitro. LÄS MER