Sökning: "transcriptional response"

Visar resultat 1 - 5 av 465 avhandlingar innehållade orden transcriptional response.

  1. 1. Biomarker discovery and assessment for prediction of kidney response after 177Lu-octreotate therapy

    Författare :Emil Schüler; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PRRT; somatostatin; radionuclide therapy; 177Lu-octreotate; scintigraphy; renal function; toxicity; kidney response; radiation biology; microarray; molecular biomarkers; ionizing radiation; miRNA; proteomics; transcriptional response;

    Sammanfattning : Patients suffering from neuroendocrine tumors are oftentimes presented with spread disease at the time of diagnosis. Therapy using somatostatin analogs is today the only potentially curative treatment option for these patients. LÄS MER

  3. 2. Nuclear receptor corepressor N-CoR : role in transcriptional repression

    Författare :Kristina Loinder; Mats Söderström; Eckardt Treuter; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The human body consists of a multitude of cells of varying appearance and function. With a few exceptions they are genetically identical, and the key to their divergence lies in their different specific patterns of gene expression. LÄS MER

  4. 3. Exploring the transcriptional space

    Författare :Joseph Bergenstråhle; Joakim Lundeberg; Jay W. Shin; KTH; []
    Nyckelord :Transcriptomics Spatial; Bioteknologi; Biotechnology;

    Sammanfattning : Transcriptomics promises biological insight into gene regulation, cell diversity, and mechanistic understanding of dysfunction. Driven by technological advancements in sequencing technologies, the field has witnessed an exponential growth in data output. Not only has the amount of raw data increased tremendously but it’s granularity as well. LÄS MER

  5. 4. Transcriptional biomarkers of toxicity – powerful tools or random noise? : An applied perspective from studies on bivalves

    Författare :Gustaf Magnus Oskar Ekelund Ugge; Olof Berglund; Annie Jonsson; Helena Westerdahl; Mikael Ejdebäck; Bruno Nunes; Högskolan i Skövde; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biomarkers; Bivalves; Bivalvia; Ecotoxicology; Environmental toxicology; Environmental risk assessment; RT-qPCR; qPCR; Quantitative PCR; Systematic review; Meta-analysis; Dose-response relationships; Concentration-response relationships; Heavy metals; Metals; General toxicity; Copper; Duck mussel; Anodonta anatina; Freshwater; Gene transcription; Biomarkörer; Musslor; Bivalvia; Ekotoxikologi; Miljötoxikologi; Miljöriskbedömning; RT-qPCR; qPCR; Kvantitativ PCR; Systematic review; Metaanalys; Dos-responssamband; Koncentration-responssamband; Tungmetaller; Metaller; Allmän toxicitet; Koppar; Allmän dammussla; Anodonta anatina; Sötvatten; Gentranskription; Ekologisk modellering; Ecological Modelling Group; Biomarkörer; Musslor; Bivalvia; Ekotoxikologi; Miljötoxikologi; Miljöriskbedömning; RT-qPCR; qPCR; Kvantitativ PCR; Systematic review; Metaanalys; Dos-responssamband; Koncentration-responssamband; Tungmetaller; Metaller; Allmän toxicitet; Koppar; Allmän dammussla; Anodonta anatina; Sötvaten; Gentranskription; Biomarkers; Bivalves; Ecotoxicology; Environmental toxicology; Environmental risk assessment; Quantitative PCR; Meta-analysis; Dose-response relationships; Concentration-response relationships; Heavy metals; Metals; General toxicity; Copper; Duck mussel; Freshwater; Gene transcription;

    Sammanfattning : Aquatic organisms are constantly at risk of being exposed to potentially harmful chemical compounds of natural or anthropogenic origin. Biological life can for instance respond to chemical stressors by changes in gene expression, and thus, certain gene transcripts can potentially function as biomarkers, i.e. LÄS MER

  7. 5. Stress response and virulence in Vibrio anguillarum

    Författare :Barbara Weber; Debra L. Milton; James D. Oliver; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Vibrio anguillarum; quorum sensing; Type VI secretion; stress response; virulence; skin colonization; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Bacteria use quorum sensing, a cell to cell signaling mechanism mediated by small molecules that are produced by specific signal molecule synthases, to regulate gene expression in response to population density. In Vibrio anguillarum, the quorum-sensing phosphorelay channels information from three hybrid sensor kinases VanN, VanQ, CqsS that sense signal molecules produced by the synthases VanM, VanS and CqsA, onto the phosphotransferase VanU, to regulate activity of the response regulator VanO. LÄS MER