Sökning: "Transcriptomics Spatial"

Visar resultat 1 - 5 av 20 avhandlingar innehållade orden Transcriptomics Spatial.

  1. 1. The Spatial Context – through the lens of method development

    Författare :Linda Kvastad; Joakim Lundeberg; Lars Feuk; KTH; []
    Nyckelord :RNA; RNA-sequencing; transcriptomics; spatial transcriptomics; single cells; pediatric brain tumors; Spatial RIN; Biotechnology; Bioteknologi;

    Sammanfattning : In the present moment of time, we find ourselves in a period where the advancement of genomic tools is progressing at a fast pace. Of particular interest for this thesis is the study of gene activity. LÄS MER

  2. 2. Spatially resolved and single cell transcriptomics

    Författare :Fredrik Salmén; Joakim Lundeberg; Patrik Ståhl; Elaine R. Mardis; KTH; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; spatial; transcriptomics; single cell; 3D; RNA-sequencing; Biotechnology; Bioteknologi;

    Sammanfattning : In recent years, massive parallel sequencing has revolutionized the field of biology and has provided us with a vast number of new discoveries in fields such as neurology, developmental biology and cancer research. A significant area is deciphering gene expression patterns, as well as other aspects of transcriptome information, such as the impact of splice variants and mutations on biological functions and disease development. LÄS MER

  3. 3. Spatial Tissue Mapping on Joint Biopsies from Arthritis Patients

    Författare :Konstantin Carlberg; Patrik Ståhl; Vivianne Malmström; Anna-Karin Hultgård Ekwall; KTH; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Immune prediction; Rheumatoid arthritis; Spatial RIN; Spatial Transcriptomics; Spondyloarthritis; Biotechnology; Bioteknologi;

    Sammanfattning : Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that mainly affects joints, causing discomfort and pain that severely reduces the life quality of affected individuals. Its etiology is largely unknown, but some pathophysiological mechanisms have been identified. LÄS MER

  4. 4. Spatially Resolved Gene Expression Analysis

    Författare :Michaela Asp; Joakim Lundeberg; Patrik Ståhl; Thierry Voet; KTH; []
    Nyckelord :RNA; RNA-sequencing; transcriptomics; spatial transcriptomics; single cells; Biotechnology; Bioteknologi;

    Sammanfattning : Spatially resolved transcriptomics has greatly expanded our knowledge of complex multicellular biological systems. To date, several technologies have been developed that combine gene expression data with information about its spatial tissue context. LÄS MER

  5. 5. Computational methods for analysis and visualization of spatially resolved transcriptomes

    Författare :Jose Fernandez Navarro; Joakim Lundeberg; Martin Hemberg; KTH; []
    Nyckelord :RNA; RNA-seq; single cell; scRNA-seq; transcriptomics; spatial transcriptomics; brain; 3D; Alzheimer’s disease; Biotechnology; Bioteknologi;

    Sammanfattning : Characterizing the expression level of genes (transcriptome) in cells and tis- sues is essential for understanding the biological processes of multicellular or- ganisms. RNA sequencing (RNA-seq) has gained traction in the last decade as a powerful tool that provides an accurate quantitative representation of the transcriptome in tissues. LÄS MER