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Visar resultat 6 - 10 av 20 avhandlingar som matchar ovanstående sökkriterier.

1. 6. Glycosaminoglycan Biosynthesis in Zebrafish

   Författare :Beata Filipek-Górniok; Lena Kjellén; Johan Ledin; Kay Grobe; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heparan sulfate; chondroitin dermatan sulfate; biosynthesis; development; N-deacetylase N-sulfotransferase; glycosyltransferases; morpholino; CRISPR-Cas9;

   Sammanfattning : Proteoglycans (PGs) are composed of highly sulfated glycosaminoglycans chains (GAGs) attached to specific core proteins. They are present in extracellular matrices, on the cell surface and in storage granules of hematopoietic cells. LÄS MER

3. 7. Heparan Sulfate and Development : A Study of NDST Deficient Mice and Embryonic Stem Cells

   Författare :Katarina Holmborn; Lena Kjellén; Erik Forsberg; Catherine L. Merry; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell and molecular biology; heparan sulfate; proteoglycan; biosynthesis; N-deacetylase N-sulfotransferase; NDST; gene targeting; embryonic development; lung development; mast cells; Cell- och molekylärbiologi;

   Sammanfattning : Heparan sulfate (HS) proteoglycans consist of sulfated HS chains covalently bound to core proteins. They are ubiquitously expressed, on the cell surface and in the extracellular matrix, throughout the body. LÄS MER

4. 8. Towards cell replacement therapy in Parkinson’s disease. Proteoglycans and Nogo-A as modulators of axonal growth in midbrain dopaminergic neurons

   Författare :Zuzanna Kurowska; Neural plasticitet och reparation; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LUHMES cells; substantia nigra pars compacta; microarray; heparan sulphate 3-O-sulfotransferase; neurocan; midbrain dopaminergic neurons; grafting; embryonic stem cells; proteoglycans; glycosaminoglycans; Nogo-A; cell replacement therapy; Parkinson’s disease;

   Sammanfattning : Parkinson’s disease (PD) is currently the second most common neurodegenerative disorder (after Alzheimer’s disease). PD is diagnosed on its motor symptoms, which include akinesia, bradykinesia, rigidity, postural imbalance and resting tremor. It is well established that the motor symptoms develop due to lack of dopamine in the striatum. LÄS MER

5. 9. Cloning and characterization of canine sulfotransferases

   Författare :Carrie Tsoi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Sulfotransferase; dog; cytosol; cloning; catalytic properties; mutagenesis;

   Sammanfattning : Sulfation generally leads to an increase in hydrophilicity facilitating increased excretion of conjugated molecules. In addition, sulfation has an important role in the synthesis, metabolism and regulation of steroid hormones as well as in the generation of reactive electrophilic forms of mutagenic heterocyclic amines and hydroxymethyl polyaromatic hydrocarbons. LÄS MER

7. 10. Cellular design of heparan sulfate : The NDST enzymes and their regulation

   Författare :Pernilla Carlsson; Lena Kjellén; Tarja Kinnunen; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; heparan sulfate; heparin; proteoglycan; NDST; PAPS; Golgi; Cell and molecular biology; Cell- och molekylärbiologi;

   Sammanfattning : Heparan sulfate proteoglycans are proteins with long, unbranched heparan sulfate (HS) polysaccharide chains attached to them. They are found on cell surfaces and in basement membranes where they exert their action by interacting with a wide range of enzymes and signaling molecules and are thereby involved in a range of various processes both during embryonic development and in adult physiology. LÄS MER