Sökning: "myoblasts"

Visar resultat 1 - 5 av 23 avhandlingar innehållade ordet myoblasts.

1. 1. Functional Studies of Genes Associated with Muscle Growth in Pigs and Hair Greying in Horses

   Författare :Lin Jiang; Leif Andersson; Kerstin Lindblad-Toh; Gerli Pielberg; Christopher Tuggle; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; QTN; muscle development; IGF2; ZBED6; RNA-seq; ChIP-seq; myoblasts; pancreatic beta cells; Grey horse; melanoma; MITF; Biologi med inriktning mot molekylär cellbiologi; Biology with specialization in Molecular Cell Biology;

   Sammanfattning : Domestic animals have become very different from their wild ancestors during domestication and animal breeding. This provides a good model to unravel the molecular mechanisms underlying phenotypic variation. In my thesis I have studied genes affecting two important traits, leanness in pigs and hair greying-associated melanoma in horses. LÄS MER

3. 2. Endogenous antioxidants in human skeletal muscle and adaption in energy metabolism : with reference to exercise-training, exercise-related factors and nutrition

   Författare :Michael B Svensson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :GSH; urate; Q10; Ubiquinone-10; myoblasts; muscle stem cells; high-intensity exercise; performance; overload training; adenine nucleotides; AMP deaminase; glycogen; carbohydrates.;

   Sammanfattning : The antioxidant homeostasis is determined by a wide array of interacting cellular antioxidants, as well as being influenced by the homeostasis in energy metabolism. Changes in antioxidant homeostasis, as a consequences of altered production of reactive oxygen species (ROS). and/or by changes in the resident levels of antioxidants. LÄS MER

4. 3. Functional characterization of the biological significance of the ZBED6/ZC3H11A locus in placental mammals

   Författare :Shady Younis; Leif Andersson; Ola Hansson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ZBED6; IGF2; ZC3H11A; Muscle development; Transcriptome analysis; CRISPR Cas9; mRNA export; Molekylär genetik; Molecular Genetics; Bioinformatik; Bioinformatics;

   Sammanfattning : The recent advances in molecular and computational biology have made possible the study of complicated transcriptional regulatory networks that control a wide range of biological processes and phenotypic traits. In this thesis, several approaches were combined including next generation sequencing, gene expression profiling, chromatin and RNA immunoprecipitation, bioinformatics and genome editing methods in order to characterize the biological significance of the ZBED6 and ZC3H11A genes. LÄS MER

5. 4. Cellular studies of neuromuscular disorders related to the sarcomeric proteins

   Författare :Saba Abdul-Hussein; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; myogenesis; myoblast; sarcomeric myopathy; TPM2; TRIM54; TRIM63;

   Sammanfattning : Sarcomere is the basic unit of cardiac and skeletal muscle contraction and its proper function requires an invariant organization of this structure. Mutations in sarcomeric proteins are known to cause increasing number of different cardiac and skeletal muscle diseases. LÄS MER

7. 5. Investigating the function of the Receptor Tyrosine Kinase ALK during Drosophila melanogaster development

   Författare :Christina Lorén; Mike Taylor; Umeå universitet; []
   Nyckelord :DAlk; receptor tyrosine kinase; Jeb; visceral muscle fusion; ERK; Drosophila; endoderm; molecular cell biology; molekylär cellbiologi;

   Sammanfattning : The Drosophila melanogaster gene Anaplastic Lymphoma Kinase (DAlk) is homologous to mammalian Alk, which is a member of the Alk/Ltk family of receptor tyrosine kinases (RTKs). In humans the t(2;5) translocation involving the Alk locus encodes an active form of Alk that is the causative agent in Non-Hodgkin’s Lymphoma (Morris et al., 1994). LÄS MER