Sökning: "spinal skada"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden spinal skada.

1. 1. Plasticity in mice nociceptive spinal circuits -role of cell adhesion molecules

   Författare :Jonas Thelin; Neurofysiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Long term-potentiation; Cell adhesion molecule; Pain; Somatosensory imprinting; Medicin människa och djur ; Medicine human and vertebrates ; Nociceptive withdrawal reflex; Species differences; Central sensitisation; Mouse strains; Spinal cord;

   Sammanfattning : Introduction: To understand the function of the genes and their products in the pain system, studies will have to deal with complex issues related to intercellular communication, e.g. plasticity in neuronal networks. LÄS MER

3. 2. Molecular mechanisms of synaptic transmission and plasticity in spinal sensory pathways

   Författare :Max Larsson; Neurofysiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurophysiology; neuropsychology; Neurology; electron microscopy; synaptic plasticity; synapse; pain; spinal cord; hyperalgesia; Neurologi; neuropsykologi; neurofysiologi;

   Sammanfattning : An intense, potentially tissue-damaging (noxious) stimulus may lead to enhanced pain sensation of subsequent noxious stimuli (hyperalgesia) and to the perceiving of innocuous stimuli as painful (allodynia). This is thought to result to a large extent from strengthening of synapses established by primary afferent fibers onto spinal cord dorsal horn neurons. LÄS MER

4. 3. PACAP and orphanin FQ/nociceptin -Distribution, importance and regulation in sensory neurons and spinal cord

   Författare :Lina Pettersson; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; neuropsychology; Neurology; trk; spinal cord; sensory neuron; rat; PAC1; PACAP; ORL1; OFQ N; neurotrophin; neuropeptide; nerve transection; nerve compression; inflammatory pain; BDNF; DRG;

   Sammanfattning : Neuropeptide expression in the nervous system is abundant and plastic, and an altered expression after injury is an example of a functional response, helping the neuron to cope with adverse changes, and involves effects on differentiation, synthesis, repair/regeneration, survival, and modulation of signal transmission. I have investigated the distribution/expression of the neuropeptides, orphanin FQ/nociceptin (OFQ/N) and pituitary adenylate cyclase activating polypeptide (PACAP), under normal conditions, in response to nerve injuries, and also studied sensory responses in mice deficient for the PAC1 receptor (PAC1-/-). LÄS MER

5. 4. Quantifying Gait Characteristics and Neurological Effects in people with Spinal Cord Injury using Data-Driven Techniques

   Författare :Minh Truong; Elena Gutierrez-Farewik; Ruoli Wang; Emelie Butler Forslund; Åke Seiger; Peter Christian Raffalt; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gait analysis; pathological gait; biomechanics; health informatics; metabolic cost; unsupervised learning; nonparametric regression; shapley addictive explanations; gånganalys; funktionsnedsättning; gångpatologi; energiförbrukning; maskininlärning; hälsoinformatik; biomekanik; AI; Teknisk mekanik; Engineering Mechanics;

   Sammanfattning : Spinal cord injury, whether traumatic or nontraumatic, can partially or completely damage sensorimotor pathways between the brain and the body, leading to heterogeneous gait abnormalities. Mobility impairments also depend on other factors such as age, weight, time since injury, pain, and walking aids used. LÄS MER

7. 5. Itch and Pain Inhibitory Mechanisms in Humans - evidence for a differential control of nociceptive senses

   Författare :Hans-Jörgen Nilsson; Neurofysiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsychology; Neurology; Human; TENS; Somatosensory; Pruritus; Analgesia; Pain; Nociception; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

   Sammanfattning : It is known that stimulation of thin nerve afferents can inhibit itch and pain and that the nociceptive systems have a detailed topographical organisation, with subsystems exhibiting specific excitatory and inhibitory receptive fields. On this basis, a new technique was developed, termed Cutaneous Field Stimulation (CFS), that electrically stimulates thin nerve fibers innervating specific skin fields. LÄS MER