Sökning: "regulatory sequence analysis"

Visar resultat 16 - 20 av 67 avhandlingar innehållade orden regulatory sequence analysis.

1. 16. Towards understanding of complex disease etiology using sequence Capture Hi-C (HiCap) and associated high throughput functional assays

   Författare :Sailendra Pradhananga; Pelin Sahlén; Joakim Lundeberg; Benedicte Alexandra Lie; KTH; []
   Nyckelord :Capture Hi-C; RNA sequencing; Whole genome sequencing; ChIP sequencing; Chromatin loops; enhancers; promoters; Bioteknologi; Biotechnology;

   Sammanfattning : A human genome laid out in a straight line would measure 2m from end to end, but in living cells it is folded into a compact structure contained in a nuclear space with a diameter of 2µm. This compact genome is hierarchically organized and spatiotemporally regulates distinct cellular gene expression mechanisms via promoter - enhancer chromatin loops. LÄS MER

3. 17. Extracellular serine proteases as virulence factors in nematophagous fungi: Molecular characterization and functional analysis of the PII protease in Arthrobotrys oligospora

   Författare :Johan Åhman; Biologiska institutionen; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; Aspergillus niger.; Heterologous expression; Over-expression; Gene-disruption; Transformation system; Serine protease; Biological control; Arthrobotrys oligospora; Fungi; Nematophagous; Biologi;

   Sammanfattning : Nematophagous fungi are parasites of nematodes, thus they have been considered and tested for biological control of parasitic nematodes, but so far with limited success. Due to the fact that the nematode cuticle is composed of proteins it is likely that fungal extracellular proteases are involved in the infection of nematodes. LÄS MER

4. 18. Genetic dissection of multifactorial disease models in the rat

   Författare :Hong Jiao; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Type 2 daibetes; Goto-Kakizaki rat; linkage analysis; quantitative trait locus; gene-gene interaction; mitochondrial sequence; parent-of-origin;

   Sammanfattning : Type 2 diabetes (T2D) is characterized by two apparently distinct pathophysiologic defects - insulin resistance and a failure of the pancreatic Beta-cells to compensate for this resistance by appropriately increasing insulin secretion. There is strong evidence for an important role of genetics in both of these components. LÄS MER

5. 19. Nucleosome positioning : impact on transcription factors access

   Författare :Qiao Li; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :glucocorticoid receptor; transcription factor; gene regulation; nucleosome; nucleosome positioning; DNA-bending sequence;

   Sammanfattning : In the eukaryotic cell nucleus, DNA is organized into nucleosomes. Some of the regulatory regions are integrated into sequence-specifically positioned nucleosomes. LÄS MER

7. 20. Regulation of HIV-1 provirus transcription

   Författare :Mojgan H Naghavi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Key words- HIV-1; LTR; transcription; subtypes; phylogenetic analysis; NFkappaB; USF; MCEF; HMG-1 DSP1; Dorsal.;

   Sammanfattning : Transcription of the HIV-genome is regulated by the interaction of viral long terminal repeat (LTR) cis-acting sequences with a complex of viral regulatory proteins and cellular transcription factors. The complex interplay between the cellular-, and/or viral proteins and LTR of different subtypes may play a role in the control of HIV-1 latency versus activation. LÄS MER