Sökning: "Capture Hi-C"

Hittade 2 avhandlingar innehållade orden Capture Hi-C.

1. 1. Towards understanding of complex disease etiology using sequence Capture Hi-C (HiCap) and associated high throughput functional assays

   Författare :Sailendra Pradhananga; Pelin Sahlén; Joakim Lundeberg; Benedicte Alexandra Lie; KTH; []
   Nyckelord :Capture Hi-C; RNA sequencing; Whole genome sequencing; ChIP sequencing; Chromatin loops; enhancers; promoters; Bioteknologi; Biotechnology;

   Sammanfattning : A human genome laid out in a straight line would measure 2m from end to end, but in living cells it is folded into a compact structure contained in a nuclear space with a diameter of 2µm. This compact genome is hierarchically organized and spatiotemporally regulates distinct cellular gene expression mechanisms via promoter - enhancer chromatin loops. LÄS MER

3. 2. Global regulation of gene expression in stem cells and regeneration

   Författare :Ilgar Abdullayev; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Rapid developments in genomics and transcriptomics fields have made it possible to ask new questions as well as solve various old problems in biology that were not achievable previously. Novel techniques such as RNA sequencing and Hi-C became available at the time I started my PhD. LÄS MER