Sökning: "Sailendra Pradhananga"

Hittade 1 avhandling innehållade orden Sailendra Pradhananga.

1. 1. Towards understanding of complex disease etiology using sequence Capture Hi-C (HiCap) and associated high throughput functional assays

   Författare :Sailendra Pradhananga; Pelin Sahlén; Joakim Lundeberg; Benedicte Alexandra Lie; KTH; []
   Nyckelord :Capture Hi-C; RNA sequencing; Whole genome sequencing; ChIP sequencing; Chromatin loops; enhancers; promoters; Bioteknologi; Biotechnology;

   Sammanfattning : A human genome laid out in a straight line would measure 2m from end to end, but in living cells it is folded into a compact structure contained in a nuclear space with a diameter of 2µm. This compact genome is hierarchically organized and spatiotemporally regulates distinct cellular gene expression mechanisms via promoter - enhancer chromatin loops. LÄS MER