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  1. 1. Studies of Cellular Regulatory Mechanisms : from Genetic Switches to Cell Migration

    Författare :Maria Werner; Erik Aurell; Ulrich Gerland; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Plasma physics; Plasmafysik;

    Sammanfattning : Cellular behaviour depends ultimately on the transcription of genes. If we know how transcription is controlled we have a better chance of understanding cellular processes. This thesis presents six studies, all concerning cellular regulatory mechanisms. One study is purely experimental and five are computational studies. LÄS MER

  3. 2. Regulatory mechanisms of amino acid-induced signaling in Saccharomyces cerevisiae

    Författare :Deike J. Omnus; Per O. Ljungdahl; Claudio De Virgilio; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Signal transduction; regulatory mechanisms; nutrient sensing; Saccharomyces cerevisiae; Cell Biology; cellbiologi;

    Sammanfattning : This thesis describes studies aimed at elucidating the molecular mechanisms that regulate the SPS (Ssy1-Ptr3-Ssy5) signal transduction pathway in the yeast Saccharomyces cerevisiae. This pathway is induced by extracellular amino acids and facilitates their uptake. LÄS MER

  4. 3. Mechanisms behind Cadmium-Induced Teratogenicity

    Författare :Estíbaliz López Fernández de Villaverde; Lennart Dencker; Ulf Eriksson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; Cadmium; Teratogenesis; Exencephaly; Mechanisms; Toxikologi; Toxicology; Toxikologi;

    Sammanfattning : Heavy metals polluting our environment cause concern for developing organisms. Among them, cadmium with extremely slow elimination from the body, causes lower birth weight in humans but has not been classify as a human teratogen. Studies in different laboratory animals have shown that cadmium indeed is a potent teratogen. LÄS MER

  5. 4. Cyanobacteria in symbiosis with plants : Protein patterns and regulatory mechanisms

    Författare :Martin Ekman; Birgitta Bergman; Dave G. Adams; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cyanobacteria; symbiosis; Nostoc; Gunnera; Azolla; nitrogenase; modification; heterotrophic; proteomics; unsequenced; Plant physiology; Växtfysiologi;

    Sammanfattning : Cyanobacteria belonging to the heterocystous genus Nostoc, capable of oxygenic photosynthesis and nitrogen fixation via the enzyme nitrogenase, may form symbiotic associations with plants. In these associations most of the N2 fixed by the symbiotic cyanobacteria (cyanobiont) is transferred to the host, which in turn supplies the cyanobiont with fixed carbon. LÄS MER

  7. 5. Regulatory Immune Responses and Repair Mechanisms in Atherosclerosis

    Författare :Sara Rattik; Kardiovaskulär forskning - immunitet och ateroskleros; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Atherosclerosis; Cardiovascular disease; T helper 2 cells; ApoB100; Regulatory B cells; Regulatory T cells; Smooth muscle cells; IL-22.;

    Sammanfattning : Atherosclerosis is a chronic inflammatory disease characterized by the formation of lipid rich plaques in the arterial wall. Rupture of a plaque results in clinical manifestations such myocardial infarction or stroke. LÄS MER