Sökning: "targeted radiotherapy"

Visar resultat 1 - 5 av 44 avhandlingar innehållade orden targeted radiotherapy.

  1. 1. Treatment selection in metastatic renal cell carcinoma : Towards an individualised approach

    Författare :Maria Stenman; Magnus Lindskog; Ulrika Harmenberg; Tim Eisen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rcc; renal cell carcinoma; kidney cancer; stereotactic radiotherapy; srt; stereotactic body radiotherapy; sbrt; gamma knife radiosurgery; gkrs; stereotactic radiosurgery; srs; radiotherapy; overall survival; prognostic factor; papillary; Oncology; Onkologi;

    Sammanfattning : Renal cell carcinoma (RCC), a common malignancy worldwide, affects 1200 new patients yearly in Sweden. Metastatic RCC (mRCC) develops in one in three and is commonly incurable. Clear cell histology dominates followed by papillary histology. LÄS MER

  3. 2. Staging and therapy response in rectal cancer

    Författare :Klara Hammarström; Tobias Sjöblom; Bengt Glimelius; Artur Mezheyeuski; Eva Angenete; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rectal cancer; radiotherapy; chemoradiotherapy; complete remission; response prediction; prognosis; targeted sequencing; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Every year, around 2,200 individuals are diagnosed with rectal cancer in Sweden. As a result of better tumour staging using magnetic resonance imaging (MRI), pre-operative radiotherapy (with or without chemotherapy), and improved surgery, outcome has improved substantially during the past few decades. LÄS MER

  4. 3. Precision medicine and targeted therapy : Turning the tables on cancer

    Författare :Anja Mortensen; Marika Nestor; Gregory Adams; Uppsala universitet; []
    Nyckelord :p53 cancers; PM2; radiosensitization; radio-immunotherapy; MDM2 X inhibition; combination therapy; targeted radionuclide therapy; CD44v6; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Sammanfattning : An extended understanding of the molecular characteristics of cancer has led to a revolution within the field of precision medicine. This thesis explores the utilization of two targets for precision medicine, namely, CD44v6 and murine double-minute 2 and X (MDM2/X). LÄS MER

  5. 4. Dosimetry Studies of Different Radiotherapy Applications using Monte Carlo Radiation Transport Calculations

    Författare :Shirin Abbasinejad Enger; Hans Lundqvist; Anders Ahnesjö; Irena Gudowska; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; External Beam Radiotherapy; Gadolinium Neutron Capture Therapy; Gadolinium Neutron Capture Brachytherapy; Targeted Radionuclide therapy; Detector Response Modelling; Monte Carlo Simulation.; Radiological physics; Radiofysik;

    Sammanfattning : Developing radiation delivery systems for optimisation of absorbed dose to the target without normal tissue toxicity requires advanced calculations for transport of radiation. In this thesis absorbed dose and fluence in different radiotherapy applications were calculated by using Monte Carlo (MC) simulations. LÄS MER

  7. 5. Targeted Therapy of Colorectal Cancer : Preclinical Evaluation of a Radiolabelled Antibody

    Författare :Ylva Almqvist; Anders Sundin; Vladimir Tolmachev; Hans Lundqvist; Matthew K Robinson; Uppsala universitet; []
    Nyckelord :Molecular medicine; tumour targeting; antibody; A33; radionuclide; colorectal cancer; therapy; Molekylärmedicin;

    Sammanfattning : Targeted radiotherapy (TRT) of cancer is a promising approach that enables selective treatment of tumour cells, while sparing normal tissue. The humanized monoclonal antibody A33 (huA33) is a potential targeting agent for TRT of colorectal cancer, since its antigen is expressed in more than 95 % of all colorectal carcinomas. LÄS MER