Sökning: "polymyxin B"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden polymyxin B.

  1. 1. Pulmonary surfactant proteins B and C : molecular organisation and involvement in respiratory disease

    Författare :Shahparak Zaltash; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Lung surfactant is a complex mixture of phospholipids and proteins with the main function to reduce the surface tension at the alveolar air/liquid interface. Surfactant protein B (SP-B) and C (SP-C) are hydrophobic but unrelated in structure, and probably have unique functional roles in the formation of the surface-active monolayer. LÄS MER

  3. 2. Inflammatory response and intervention in experimental acute pancreatitis

    Författare :Changbin Shi; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kirurgi; ortopedi; traumatologi; traumatology; Surgery; orthopaedics; signalling pathways; protein kinase C; nuclear factor-kB; leukocytes; inflammatory mediators; immunosuppression; acute pancreatitis; extracellular signal-regulated kinase;

    Sammanfattning : Acute pancreatitis (AP) is a common disease where underlying mechanisms for the local initiating events in the pancreas, the systemic dissemination of the inflammatory response and remote organ dysfunction still are unclear. The overall aim of the thesis was to study mechanisms of the inflammatory response in AP with special emphasis on local, systemic, and distant organ injury directed at different signalling pathways, and potential therapeutic strategies to prevent the development of inflammation and cell injury following AP. LÄS MER

  4. 3. Exploring the interactions of antibiotic combinations against multidrug-resistant Gram-negative bacteria

    Författare :Anna Olsson; Thomas Tängdén; Linus Sandegren; Pernilla Lagerbäck; Joseph Meletiadis; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gram-negative bacteria combination therapy antimicrobial resistence; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Antimicrobial resistance is emerging and available treatment options are lacking. Antibiotics is a cornerstone in modern medicine where medical procedures such as surgery, care of premature babies or treatment of cancer is dependent on efficient drugs. LÄS MER

  5. 4. Immunochemical characterisation of Brucella LPS and its relation to virulence

    Författare :Enrique Freer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Brucella abortus Brucella ovis Bacterial lipopolysaccharide LPS : LPS heterogeneity Virulence factors Cationic peptides.;

    Sammanfattning : Members of the genus Brucella are facultative intracellular pathogens which infect and produce disease in a wide variety of mammals. Although some factors have been implicated in the virulence of Brucella, the virulence mechanisms of this intracellular pathogen are not known. LÄS MER

  7. 5. Quantifying effects of antimicrobial drug combinations by modelling and simulation

    Författare :Chenyan Zhao; Lena Friberg; Elisabet I. Nielsen; Shampa Das; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics and pharmacodynamics; modelling and simulation; antibiotic combination; model-based translation; antibiotic resistance; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Antibiotic resistance is becoming an accelerating issue, both in the treatment of nosocomial infections and for public health in general. There is a pressing need for innovative methods to understand how available antibiotics could be combined to overcome and limit the emergence of resistance. LÄS MER