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Visar resultat 21 - 25 av 28 avhandlingar som matchar ovanstående sökkriterier.

1. 21. Immune and autoimmune responses to HIV-1 in mucosa and other tissues

   Författare :Peter Lundholm; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The aim of these studies was to evaluate routes and devices for administration of HIV-1 DNA vaccines. In particular we were interested in mucosal routes for the induction of immunity at mucosal surfaces. We studied the effects of a novel mucosal route, jet-injection, for induction of systemic and local responses. LÄS MER

3. 22. Preclinical studies of ribozyme-mediated gene therapy for HIV-1

   Författare :Catharina Maijgren Steffensson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :AIDS; antiretroviral; cis-cleavage; gene therapy; HAART; hairpin; hammerhead; HIV-1; in vitro; in vivo; ribozyme; RNA;

   Sammanfattning : Approximately 40 million people are infected with HIV-1 and AIDS is the number one cause of death in Africa as well as, the fourth leading cause of death globally. Patients in developed countries generally receive highly active antiretroviral therapy (HAART), even though the drugs are expensive and sometimes cause side-effects and treatment failure. LÄS MER

4. 23. Leukemia inhibitor factor (LIF) and gp130 in early defence against HIV-1 infection

   Författare :Annelie Tjernlund; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :LIF; HIV-1; lymphoid tissue; cytokine; innate immune response; Jak Stat signalling pathway; cMAGI cells; siRNA;

   Sammanfattning : Leukemia inhibitor factor (LIF) is a polyfunctional cytokine that belongs to the IL-6 family which mainly signals through the Jak/Stat pathway via the gp130/LIFR-α heterodimer. The focus of my research has been to investigate and understand if and how LIF exerts HIV1 suppressing activity. LÄS MER

5. 24. Studies on experimental neonatal CNS infection : implications for neuropsychiatric disorders

   Författare :Linnéa Asp; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Despite extensive research the etiologies of neuropsychiatric disorders such as schizophrenia remain obscure. It is currently believed that complex interactions between a number of genetic and environmental risk factors contribute to the development of these disorders. LÄS MER

7. 25. In vivo and in vitro models for determination of antiviral activity and resistance

   Författare :Ewa Ljungdahl Ståhle; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The AIDS epidemic has been the driving force for the discovery of substances that inhibit the replication of human immunodeficiency virus (HIV). Much interest has earlier focused on a single gene product central to the life cycle of HIV and to all other retroviruses: the reverse transcriptase (RT), the enzyme responsible for synthesis of DNA from viral RNA. LÄS MER