Sökning: "neuropathic"

Visar resultat 16 - 20 av 98 avhandlingar innehållade ordet neuropathic.

  1. 16. The Impact of the Neuropeptide Substance P (SP) Fragment SP1-7 on Chronic Neuropathic Pain

    Författare :Anna Jonsson; Fred Nyberg; Mathias Hallberg; James Zadina; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropathic pain; substance P SP ; SP1-7; bioactive fragments; spared nerve injury; spinal cord injury; streptozotocin-induced diabetes; allodynia; hyperalgesia; peptidomimetics; cerebrospinal fluid; spinal cord stimulation; radioimmunoassay; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : There is an unmet medical need for the efficient treatment of neuropathic pain, a condition that affects approximately 10% of the population worldwide. Current therapies need to be improved due to the associated side effects and lack of response in many patients. LÄS MER

  3. 17. Drug-enhanced spinal cord stimulation for neuropathic pain : studies on neurochemical mechanisms and clinical applications

    Författare :Gastón Schechtmann; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Acetylcholine; baclofen; cholinergic analgesia; clonidine; gabapentin; neuropathic pain; nerve injury; pregabalin; spinal cord stimulation; intrathecal drug;

    Sammanfattning : Spinal cord stimulation (SCS) is an effective surgical treatment for neuropathic pain refractory to pharmacological therapy. For many patients suffering from this type of chronic pain, SCS is in fact the ultimate treatment option. LÄS MER

  4. 18. The role of adenosine and its receptor subtypes in nociception and neuropathic pain

    Författare :Weiping Wu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Adenosine; adenosine receptors; antinociception; caffeine; knock-out mouse; neuropathy; morphine; R-PIA;

    Sammanfattning : As neurotransmitter/modulator, adenosine plays an important role in nociceptive processing. Adenosine receptors are G-protein coupled and four receptor subtypes, A1, A2A, A2B and A3 have been identified. It is well established that adenosine and its receptor agonists produce primarily antinociceptive effect in animals and humans. LÄS MER

  5. 19. Experimental and clinical studies on adenosine receptor stimulation in cutaneous hypersensitivity and neuropathic pain

    Författare :Karl-Fredrik Sjölund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Adenosine agonists; allodynia; central sensitization; hyperalgesia; nociception; pain;

    Sammanfattning : The endogenous compound adenosine (ADO) has a wide range of physiological effects. Numerous animal studies and a limited number of human studies have shown antinociceptive effects of ADO and its analogues. The spinal cord dorsal column, where ADO receptors are found in high numbers, is a major site of action for this effect. LÄS MER

  7. 20. Quantitative and qualitative analysis of touch, cold and warmth in health, neuropathic pain and fibromyalgia

    Författare :Eva-Liz Harju; Gary B Rollman; Stockholms universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Ongoing pain; tactile and thermal dys function; perceived intensity; Master Scaling; perceived quality; Känsel; Smärta; fysiologisk psykologi; Fibromyalgi; psykologi; Psychology;

    Sammanfattning : The general aim of the present thesis is to examine tactile and thermal perceptual (dys)function by quantitative and qualitative tests of patients with neuropathic pain or fibromyalgia, and to compare results with those of healthy persons. A specific aim is to provide individual data for diagnostic purposes, specific to touch, cold, and warmth (profiles). LÄS MER