Sökning: "Adenosine agonists"
Visar resultat 1 - 5 av 17 avhandlingar innehållade orden Adenosine agonists.
1. Studies of nucleotide receptors-induced calcium response in glomerular mesangial cells and afferent arterioles
Sammanfattning : It is known that intracellular calcium concentration ([Ca2+]i) changes in rat glomerular mesangial cells (GMC) and rabbit afferent arterioles (AA) in response to extracellular nucleotides. We studied the nucleotide-induced calcium response in cultured GMC and AA. LÄS MER
2. Adenosine receptor/dopamine receptor interactions : molecular and biochemical aspects
Sammanfattning : The dopamine receptors have been shown to be involved in a variety of higher brain functions, such as motor control, cognition and affective states. Agonist and antagonists of dopamine receptors are widely used to treat disorders such as Parkinson's disease and schizophrenia, respectively. LÄS MER
3. Adenosine A2A and ATP receptors in PC12 cells
Sammanfattning : PC12 cells, originally isolated from a rat pheochromocytoma, are widely used to study receptor pharmacology and nerve cell differentiation. They are the neoplastic counterpart of adrenal chromaffin cells, but upon treatment with NGF they acquire a neuronal phenotype. LÄS MER
4. Experimental and clinical studies on adenosine receptor stimulation in cutaneous hypersensitivity and neuropathic pain
Sammanfattning : The endogenous compound adenosine (ADO) has a wide range of physiological effects. Numerous animal studies and a limited number of human studies have shown antinociceptive effects of ADO and its analogues. The spinal cord dorsal column, where ADO receptors are found in high numbers, is a major site of action for this effect. LÄS MER
5. The role of adenosine and its receptor subtypes in nociception and neuropathic pain
Sammanfattning : As neurotransmitter/modulator, adenosine plays an important role in nociceptive processing. Adenosine receptors are G-protein coupled and four receptor subtypes, A1, A2A, A2B and A3 have been identified. It is well established that adenosine and its receptor agonists produce primarily antinociceptive effect in animals and humans. LÄS MER