Sökning: "gabapentin"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet gabapentin.

  1. 1. Drug-enhanced spinal cord stimulation for neuropathic pain : studies on neurochemical mechanisms and clinical applications

    Författare :Gastón Schechtmann; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Acetylcholine; baclofen; cholinergic analgesia; clonidine; gabapentin; neuropathic pain; nerve injury; pregabalin; spinal cord stimulation; intrathecal drug;

    Sammanfattning : Spinal cord stimulation (SCS) is an effective surgical treatment for neuropathic pain refractory to pharmacological therapy. For many patients suffering from this type of chronic pain, SCS is in fact the ultimate treatment option. LÄS MER

  3. 2. Sinomenine as a novel analgesic : mechanisms and applications

    Författare :Tiansheng Shi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic pain of various origins is a major health care issue affecting a large patient population, also bring significant social and economic cost on the society. Work presented in this thesis concerns novel methods of treatments for chronic pain using experimental models. LÄS MER

  4. 3. Experimental nerve injury : induced pain : mechanisms and modulation

    Författare :Johan Wallin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic nerve injury-induced pain presents a therapeutic challenge since such pain is often resistant to conventional analgesic drugs including opioids. Better knowledge of the pathophysiological mechanisms underlying nerve injuryinduced pain is necessary to develop new and more efficacious therapies. LÄS MER

  5. 4. The analgesic mechanisms of buprenorphine

    Författare :Poli Francois Kouya; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Buprenorphine; morphine; cross-tolerance; g- opioid receptors; inbred mice.;

    Sammanfattning : Buprenorphine, a derivative of thebaine, is a semi-synthetic opiate and a partial p-opioid receptor agonist. Buprenorphine is also a weak kappa-opioid receptor antagonist. Buprenorphine is used clinically as an analgesic and for maintenance therapy of opiate-dependent subjects because it produces limited withdrawal symptoms. LÄS MER

  7. 5. Development of Substance P 1–7 Related Peptides and Peptidomimetics : Targeting Neuropathic Pain

    Författare :Anna Skogh; Anja Sandström; Christian Sköld; Rebecca Fransson; Philip Thompson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Substance P 1–7; Peptidomimetics; Solid-phase Peptide Synthesis SPPS ; Palladium catalysis; Carbonylation; Imidazole; Bioisostere; Neuropathic pain; Allodynia; Structure-activity relationships; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : The neuropeptide substance P 1–7 (SP1–7, H-Arg1-Pro2-Lys3-Pro4-Gln5-Gln6-Phe7-OH) and its amidated analogue SP1–7 amide, have displayed intriguing effects in experimental models for neuropathic pain acting on a specific, yet unknown SP1–7 target. The aim of this thesis was to design and synthesise SP1–7 related peptides and peptidomimetics, to be used as research tools to study the SP1–7 system, and to serve as drug leads in the neuropathic pain area. LÄS MER