Sökning: "mitochondrial function"

Visar resultat 1 - 5 av 307 avhandlingar innehållade orden mitochondrial function.

  1. 1. Mitochondrial translation and its impact on protein homeostasis and aging

    Författare :Tamara Suhm; Martin Ott; Aleksandra Trifunovic; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mitochondrial ribosome; mitochondrial translation accuracy; mitochondrial communication; interorganellar communication; stress signaling; proteostasis; aging; yeast genetics; mitochondrial protein quality control; mitochondrial membrane protein insertion; Biochemistry; biokemi;

    Sammanfattning : Besides their famous role as powerhouse of the cell, mitochondria are also involved in many signaling processes and metabolism. Therefore, it is unsurprising that mitochondria are no isolated organelles but are in constant crosstalk with other parts of the cell. LÄS MER

  3. 2. Mitochondrial Energy Metabolism : Kgd4 is a novel subunit of the α-ketoglutarate dehydrogenase complex

    Författare :Manfred Heublein; Martin Ott; Flavia Fontanesi; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mitochondria; α-ketoglutarate dehydrogenase; Kgd4; Krebs cycle; Biochemistry; biokemi;

    Sammanfattning : Mitochondria are essential organelles of eukaryotic cells and are responsible for their energy metabolism. The citric acid cycle, a chain of redox reactions in the mitochondrial matrix, is a central metabolic hub. LÄS MER

  4. 3. Mitochondrial Iron Metabolism : Study of mitoferrin in Drosophila melanogaster

    Författare :Christoph Metzendorf; Maria Lind Karlberg; Kenneth Söderhäll; Martina Muckenthaler; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; iron; Drosophila; mitochondria; mitoferrin; ferritin; spermatogenesis; cell cycle; DFO; MRS12; Cell and molecular biology; Cell- och molekylärbiologi; Biology with specialization in Comparative Physiology; Biologi med inriktning mot jämförande fysiologi;

    Sammanfattning : Iron has a dualistic character. On the one hand it is essential for the life of most organisms, on the other hand it is involved in the generation of reactive oxygen species that are implicated in diseases and aging. LÄS MER

  5. 4. Mitochondrial medicine. New strategies to evaluate drug toxicity and develop pharmacological protection of the cell’s powerhouse

    Författare :Sarah Piel; Klinisk neurofysiologi; []
    Nyckelord :mitochondria; drug-induced mitochondrial toxicity; mitochondrial disease; mitochondrial medicine; drug development; succinate; methylene blue; metformin; acetaminophen; paracetamol; Kolliphor® EL;

    Sammanfattning : Mitochondria produce the majority of the cell’s energy. Any dysfunction in, or interference with mitochondrial function can have severe consequences. And yet, it was only within the last decades that screening for potential mitochondrial toxicity was included as routine toxicity assay during early drug development. LÄS MER

  7. 5. Organization and regulation of mitochondrial gene expression

    Författare :Roger Salvatori; Martin Ott; Benoit Kornmann; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mitochondria; mitochondrial gene expression; post-transcriptional regulation; mitochondrial ribosome; protein-protein proximity; BioID; feedback loop; Biochemistry; biokemi;

    Sammanfattning : Mitochondria possess their own genome, remnant of the ancestral eubacterial endosymbiont DNA. This mitochondrial genome encodes mostly few key subunits of the respiratory chain. In order to synthesize these few proteins, mitochondria contain a complete gene expression machinery. LÄS MER