Sökning: "mitochondrial translation accuracy"

Hittade 4 avhandlingar innehållade orden mitochondrial translation accuracy.

  1. 1. Mitochondrial translation and its impact on protein homeostasis and aging

    Författare :Tamara Suhm; Martin Ott; Aleksandra Trifunovic; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mitochondrial ribosome; mitochondrial translation accuracy; mitochondrial communication; interorganellar communication; stress signaling; proteostasis; aging; yeast genetics; mitochondrial protein quality control; mitochondrial membrane protein insertion; Biochemistry; biokemi;

    Sammanfattning : Besides their famous role as powerhouse of the cell, mitochondria are also involved in many signaling processes and metabolism. Therefore, it is unsurprising that mitochondria are no isolated organelles but are in constant crosstalk with other parts of the cell. LÄS MER

  3. 2. From Structure to Function with Binding Free Energy Calculations for Codon Reading, Riboswitches and Lectins

    Författare :Johan Sund; Åqvist Johan; Javier Luque; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; binding free energy; ribosome; codon reading; release factor; mitochondrial translation; purine riboswitch; lectin; molecular dynamics; free energy perturbation; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi;

    Sammanfattning : Molecular association is part of many important processes in living cells. Computational methods for calculating binding free energies allows for a quantitative examination of biomolecular structures and hypotheses drawn from biochemical experiments. LÄS MER

  4. 3. Controlling protein homeostasis through regulation of Heat shock factor 1

    Författare :Anna E. Masser; Claes Andréasson; Marie Öhman; David Pincus; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; stress; protein homeostasis; molecular chaperones; heat shock response; Hsf1; Hsp70; Saccharomyces cerevisiae; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : In order to thrive in a changing environment all organisms need to ensure protein homeostasis (proteostasis). Proteostasis is ensured by the proteostasis system that monitors the folding status of the proteome and regulates cell physiology and gene expression to counteract any perturbations. LÄS MER

  5. 4. Interorganellar connectivity : From protein to lipid homeostasis

    Författare :Carlotta Peselj; Sabrina Büttner; Tim Levine; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Interorganellar connectivity; nucleus; NVJs; chronic lipid bilayer stress; glucose and phosphate exhaustion; nutritional regimes; transmembrane chaperone; IPTP; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Interorganellar connectivity is fundamental for the maintenance of organellar and cellular functionality and viability. This is achieved and maintained by a complex network of signaling cascades, vesicle trafficking between organelles as well as by establishment of direct physical contact at membrane contact sites (MCS). LÄS MER