Sökning: "metabolic signature"

Visar resultat 1 - 5 av 17 avhandlingar innehållade orden metabolic signature.

  1. 1. Cardiovascular morbidity and metabolic signature in patients with rheumatoid arthritis

    Författare :Mitra Nadali; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiovascular mortality; Rheumatoid arthritis; metabolic signature;

    Sammanfattning : Background and objectives: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease with excess risk for cardiovascular morbidity and mortality. The treatment of RA by anti-inflammatory drugs has dramatically been improved over the resent decades. LÄS MER

  3. 2. Systems Biology of Type 2 Diabetes in Skeletal Muscle

    Författare :Leif Väremo; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; genome-scale metabolic model; metabolism; skeletal muscle; myocyte; type 2 diabetes; network analysis; gene-set analysis; transcriptomics; gene expression; obesity;

    Sammanfattning : Type 2 diabetes (T2D) is a heterogeneous and complex disease that currently affects more than 350 million people worldwide. A wide range of risk factors influence the pathogenesis of T2D, including genetic and epigenetic components, as well as controllable factors such as diet, obesity, and sedentary lifestyle. LÄS MER

  4. 3. Metabolite Alterations and Cardiometabolic Disease: A Nutritional Perspective

    Författare :Einar Smith; Kardiovaskulär forskning - hypertoni; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metabolomics; Nutrition; Nutritional metabolomics; Biomarkers; Cardiometabolic disease; Cardiovascular disease; Type 2 diabetes; Prospective cohort studies; Dietary intervention;

    Sammanfattning : Background Cardiovascular disease (CVD), type 2 diabetes (T2DM), and atrial fibrillation (AF) collectively impact millions globally, necessitating a comprehensive understanding of preceding metabolic alterations for early intervention. This thesis aims to explore metabolic shifts across populations-based cohorts and evaluate the metabolic impact of a dietary intervention. LÄS MER

  5. 4. Immunometabolic regulation in natural HIV-1 control

    Författare :Maike Sperk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The elite controllers (EC) are a rare group of people living with HIV-1 infection (PLHIV) that can control viral replication in the absence of antiretroviral therapy for a prolonged time. The mechanisms behind elite control phenotype leading to viral suppression are not fully elucidated. LÄS MER

  7. 5. Rho-GTPases in Rheumatoid Arthritis

    Författare :Eric Malmhäll-Bah; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rho-GTPases; rheumatoid arthritis; innate immunity; adaptive immunity; RA treatment;

    Sammanfattning : The success of alleviating rheumatoid arthritis (RA) symptoms is complicated by both heterogeneity of the disease and lack of predictive markers to guide treatment options. Deregulated Rho-GTPases, a family of hydrolase enzymes catalyzing guanosine triphospate (GTP) to guanosine diphospate (GDP), have a detrimental role in many diseases including RA. LÄS MER