Sökning: "gene-set analysis"

Visar resultat 1 - 5 av 22 avhandlingar innehållade orden gene-set analysis.

  1. 1. Systems Biology of Type 2 Diabetes in Skeletal Muscle

    Författare :Leif Väremo; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; genome-scale metabolic model; metabolism; skeletal muscle; myocyte; type 2 diabetes; network analysis; gene-set analysis; transcriptomics; gene expression; obesity;

    Sammanfattning : Type 2 diabetes (T2D) is a heterogeneous and complex disease that currently affects more than 350 million people worldwide. A wide range of risk factors influence the pathogenesis of T2D, including genetic and epigenetic components, as well as controllable factors such as diet, obesity, and sedentary lifestyle. LÄS MER

  3. 2. Global functional association network inference and crosstalk analysis for pathway annotation

    Författare :Christoph Ogris; Erik Sonnhammer; Alfonso Valencia; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biological networks; genome wide functional association networks; global gene association networks; gene networks; protein networks; functional association; functional coupling; network biology pathway analysis; pathway annotation; pathway enrichment; network-based enrichment; enrichment; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

    Sammanfattning : Cell functions are steered by complex interactions of gene products, like forming a temporary or stable complex, altering gene expression or catalyzing a reaction. Mapping these interactions is the key in understanding biological processes and therefore is the focus of numerous experiments and studies. LÄS MER

  4. 3. Biomarkers of Inflammation and Intestinal Mucosa Pathology in Celiac Disease

    Författare :Hanna Gustafsson Bragde; Jan Söderman; Ulf Jansson; Ewa Grodzinsky; Mats Fredrikson; Ross McManus; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Celiac disease (CD) is a chronic small intestinal immune-mediated enteropathy triggered by gluten. The only currently available treatment is complying with a lifelong gluten-free diet, which should not be commenced before a CD diagnosis has been established by diagnostic test results (including histopathologic assessment of small intestinal biopsies and CD-specific antibody levels). LÄS MER

  5. 4. Regulation of fibroblast activity by keratinocytes, TGF-β and IL-1α : studies in two- and three dimensional in vitro models

    Författare :Anita Koskela von Sydow; Mikael Ivarsson; Torbjörn Bengtsson; Hans Törmä; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fibroblast; Keratinocyte; TGF-β; IL-1α; coculture; fibrosis CTGF CNN 2; dermal; organotypic culture;

    Sammanfattning : Dysregulated wound healing is commonly associated with excessive fibrosis. Connective tissue growth factor (CTGF/CCN2) is characteristically overexpressed in fibrotic diseases and stimulated by transforming growth factor-β (TGF-β) in dermal fibroblasts. Reepithelialisation and epidermal wound coverage counteract excessive scar formation. LÄS MER

  7. 5. Methods and Applications in Comparative Bacterial Genomics

    Författare :Hans-Henrik Fuxelius; Siv Andersson; Björn Andersson; Uppsala universitet; []
    Nyckelord :Biology; Biologi;

    Sammanfattning : Comparative studies of bacterial genomes, now counting in the hundreds, generate massive amounts of information. In order to support a systematic and efficient approach to genomic analyses, a database driven system with graphic visualization of genomic properties was developed - GenComp. LÄS MER